Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles
Abstract The application of lipid‐based nanoparticles for COVID‐19 vaccines and transthyretin‐mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous o...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202305769 |
| _version_ | 1797299307652579328 |
|---|---|
| author | Soraia Fernandes Marco Cassani Francesca Cavalieri Giancarlo Forte Frank Caruso |
| author_facet | Soraia Fernandes Marco Cassani Francesca Cavalieri Giancarlo Forte Frank Caruso |
| author_sort | Soraia Fernandes |
| collection | DOAJ |
| description | Abstract The application of lipid‐based nanoparticles for COVID‐19 vaccines and transthyretin‐mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid‐based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid‐based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid‐based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes. |
| first_indexed | 2024-03-07T22:48:41Z |
| format | Article |
| id | doaj.art-96fa762f277b4befbd22cb6fc2da2828 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-07T22:48:41Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-96fa762f277b4befbd22cb6fc2da28282024-02-23T12:47:39ZengWileyAdvanced Science2198-38442024-02-01118n/an/a10.1002/advs.202305769Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based NanoparticlesSoraia Fernandes0Marco Cassani1Francesca Cavalieri2Giancarlo Forte3Frank Caruso4Center for Translational Medicine (CTM) International Clinical Research Centre (ICRC) St. Anne Hospital Brno 656 91 Czech RepublicCenter for Translational Medicine (CTM) International Clinical Research Centre (ICRC) St. Anne Hospital Brno 656 91 Czech RepublicSchool of Science RMIT University Melbourne Victoria 3000 AustraliaCenter for Translational Medicine (CTM) International Clinical Research Centre (ICRC) St. Anne Hospital Brno 656 91 Czech RepublicDepartment of Chemical Engineering The University of Melbourne Parkville Victoria 3010 AustraliaAbstract The application of lipid‐based nanoparticles for COVID‐19 vaccines and transthyretin‐mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid‐based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of lipid‐based nanoparticles for immunotherapy is projected to revolutionize cancer therapy, with the ultimate goal of rendering cancer a chronic disease. However, the translational success is likely to depend on the use of predictive tumor models in preclinical studies, simulating the complexity of the tumor microenvironment (e.g., the fibrotic extracellular matrix that impairs therapeutic outcomes) and stimulating tumor progression. This review compiles recent advances in the field of antitumor lipid‐based nanoparticles and highlights emerging therapeutic approaches (e.g., mechanotherapy) to modulate tumor stiffness and improve T cell infiltration, and the use of organoids to better guide therapeutic outcomes.https://doi.org/10.1002/advs.202305769ECMimmunotherapylipid‐based nanoparticlesmechanotherapytumor |
| spellingShingle | Soraia Fernandes Marco Cassani Francesca Cavalieri Giancarlo Forte Frank Caruso Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles Advanced Science ECM immunotherapy lipid‐based nanoparticles mechanotherapy tumor |
| title | Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles |
| title_full | Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles |
| title_fullStr | Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles |
| title_full_unstemmed | Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles |
| title_short | Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid‐Based Nanoparticles |
| title_sort | emerging strategies for immunotherapy of solid tumors using lipid based nanoparticles |
| topic | ECM immunotherapy lipid‐based nanoparticles mechanotherapy tumor |
| url | https://doi.org/10.1002/advs.202305769 |
| work_keys_str_mv | AT soraiafernandes emergingstrategiesforimmunotherapyofsolidtumorsusinglipidbasednanoparticles AT marcocassani emergingstrategiesforimmunotherapyofsolidtumorsusinglipidbasednanoparticles AT francescacavalieri emergingstrategiesforimmunotherapyofsolidtumorsusinglipidbasednanoparticles AT giancarloforte emergingstrategiesforimmunotherapyofsolidtumorsusinglipidbasednanoparticles AT frankcaruso emergingstrategiesforimmunotherapyofsolidtumorsusinglipidbasednanoparticles |