Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review
Abstract Purpose This systematic review aimed to evaluate the effects of concurrent cartilage procedures on cartilage regeneration when performed alongside high tibial osteotomy (HTO). Materials and methods The systematic review followed the guidelines outlined in the Preferred Reporting Items for S...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Knee Surgery & Related Research |
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| Online Access: | https://doi.org/10.1186/s43019-024-00221-w |
| _version_ | 1797233472365920256 |
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| author | Joo Hyung Han Min Jung Kwangho Chung Se-Han Jung Chong-Hyuk Choi Sung-Hwan Kim |
| author_facet | Joo Hyung Han Min Jung Kwangho Chung Se-Han Jung Chong-Hyuk Choi Sung-Hwan Kim |
| author_sort | Joo Hyung Han |
| collection | DOAJ |
| description | Abstract Purpose This systematic review aimed to evaluate the effects of concurrent cartilage procedures on cartilage regeneration when performed alongside high tibial osteotomy (HTO). Materials and methods The systematic review followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A comprehensive search was conducted on databases including PubMed, Embase, Cochrane Library, and Google Scholar, covering articles published until August 31, 2023. Results Sixteen studies (1277 patients) revealed that HTO, with or without concurrent cartilage procedures, leads to cartilage regeneration based on the International Cartilage Repair Society (ICRS) grade during second-look arthroscopy. No concurrent procedure showed improvement in ICRS grade (mean difference: − 0.80 to − 0.49). Microfracture (mean difference: − 0.75 to − 0.22), bone marrow aspirate concentrate (BMAC) (mean difference: − 1.37 to − 0.67), and human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) (mean difference: − 2.46 to − 1.81) procedures also demonstrated positive outcomes. Clinical outcome assessments for each cartilage procedure were also improved during postoperative follow-up, and no specific complications were reported. Conclusions HTO with or without concurrent cartilage procedures promotes cartilage regeneration observed during second-look arthroscopy, with improved clinical outcomes. Future randomized controlled trials on the same topic, along with subsequent meta-analyses, are necessary for conclusive findings. |
| first_indexed | 2024-04-24T16:16:43Z |
| format | Article |
| id | doaj.art-96fadbc551624b679a41225083627637 |
| institution | Directory Open Access Journal |
| issn | 2234-2451 |
| language | English |
| last_indexed | 2024-04-24T16:16:43Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Knee Surgery & Related Research |
| spelling | doaj.art-96fadbc551624b679a412250836276372024-03-31T11:24:00ZengBMCKnee Surgery & Related Research2234-24512024-03-0136111310.1186/s43019-024-00221-wEffects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic reviewJoo Hyung Han0Min Jung1Kwangho Chung2Se-Han Jung3Chong-Hyuk Choi4Sung-Hwan Kim5Department of Orthopedic Surgery, Yonsei University College of MedicineDepartment of Orthopedic Surgery, Arthroscopy and Joint Research Institute, Yonsei University College of MedicineDepartment of Orthopedic Surgery, Arthroscopy and Joint Research Institute, Yonsei University College of MedicineDepartment of Orthopedic Surgery, Arthroscopy and Joint Research Institute, Yonsei University College of MedicineDepartment of Orthopedic Surgery, Arthroscopy and Joint Research Institute, Yonsei University College of MedicineDepartment of Orthopedic Surgery, Arthroscopy and Joint Research Institute, Yonsei University College of MedicineAbstract Purpose This systematic review aimed to evaluate the effects of concurrent cartilage procedures on cartilage regeneration when performed alongside high tibial osteotomy (HTO). Materials and methods The systematic review followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A comprehensive search was conducted on databases including PubMed, Embase, Cochrane Library, and Google Scholar, covering articles published until August 31, 2023. Results Sixteen studies (1277 patients) revealed that HTO, with or without concurrent cartilage procedures, leads to cartilage regeneration based on the International Cartilage Repair Society (ICRS) grade during second-look arthroscopy. No concurrent procedure showed improvement in ICRS grade (mean difference: − 0.80 to − 0.49). Microfracture (mean difference: − 0.75 to − 0.22), bone marrow aspirate concentrate (BMAC) (mean difference: − 1.37 to − 0.67), and human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) (mean difference: − 2.46 to − 1.81) procedures also demonstrated positive outcomes. Clinical outcome assessments for each cartilage procedure were also improved during postoperative follow-up, and no specific complications were reported. Conclusions HTO with or without concurrent cartilage procedures promotes cartilage regeneration observed during second-look arthroscopy, with improved clinical outcomes. Future randomized controlled trials on the same topic, along with subsequent meta-analyses, are necessary for conclusive findings.https://doi.org/10.1186/s43019-024-00221-wHigh tibial osteotomyHuman umbilical cord blood-derived mesenchymal stem cellBone marrow aspirate concentrateMicrofractureCartilage regenerationSecond-look arthroscopy |
| spellingShingle | Joo Hyung Han Min Jung Kwangho Chung Se-Han Jung Chong-Hyuk Choi Sung-Hwan Kim Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review Knee Surgery & Related Research High tibial osteotomy Human umbilical cord blood-derived mesenchymal stem cell Bone marrow aspirate concentrate Microfracture Cartilage regeneration Second-look arthroscopy |
| title | Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review |
| title_full | Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review |
| title_fullStr | Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review |
| title_full_unstemmed | Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review |
| title_short | Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review |
| title_sort | effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy a systematic review |
| topic | High tibial osteotomy Human umbilical cord blood-derived mesenchymal stem cell Bone marrow aspirate concentrate Microfracture Cartilage regeneration Second-look arthroscopy |
| url | https://doi.org/10.1186/s43019-024-00221-w |
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