RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5′-UTR

RNA sensor MDA5 suppresses LINE-1 retrotransposition by regulating the promoter activity of LINE-1 5′-UTR

Abstract Background Type 1 long interspersed elements, or LINE-1, are the only retroelements that replicate autonomously in human cells. The retrotransposition process of LINE-1 can trigger the activation of the innate immune system and has been proposed to play a role in the development of several...

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Bibliographic Details
Main Authors: Jiaxiu Yan, Yifei Zhao, Juan Du, Yu Wang, Shaohua Wang, Qing Wang, Xu Zhao, Wei Xu, Ke Zhao
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Mobile DNA
Subjects:
LINE-1
MDA5
Retrotransposition
5′-UTR
Promoter regulation
Online Access:https://doi.org/10.1186/s13100-022-00268-0

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