Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study
In order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2192 |
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| author | Niels R. van der Werf Margo van Gent Ronald Booij Daniel Bos Aad van der Lugt Ricardo P. J. Budde Marcel J. W. Greuter Marcel van Straten |
| author_facet | Niels R. van der Werf Margo van Gent Ronald Booij Daniel Bos Aad van der Lugt Ricardo P. J. Budde Marcel J. W. Greuter Marcel van Straten |
| author_sort | Niels R. van der Werf |
| collection | DOAJ |
| description | In order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at two heart rates: 0 and 60–75 beats per minute (bpm). Five imaging protocols were used: 120 kVp standard dose (IQ level 16, reference), 90 kVp at standard (IQ level 16), 75% and 45% dose and tin-filtered 100 kVp at standard dose (IQ level 16). Each scan was repeated five times. Images were reconstructed using monoE reconstruction at 70 keV. For each heart rate, CAC values, quantified as Agatston scores, were compared with the reference, whereby deviations >10% were deemed clinically relevant. Reference protocol radiation dose (as volumetric CT dose index) was 4.06 mGy. Radiation dose was reduced by 27%, 44%, 67%, and 46% for the 90 kVp standard dose, 90 kVp 75% dose, 90 kVp 45% dose, and Sn100 standard dose protocol, respectively. For the low-density CAC, all reduced tube current protocols resulted in clinically relevant differences with the reference. For the medium- and high-density CAC, the implemented 90 kVp protocols and heart rates revealed no clinically relevant differences in Agatston score based on 95% confidence intervals. In conclusion, PCCT allows for reproducible Agatston scores at a reduced tube voltage of 90 kVp with radiation dose reductions up to 67% for medium- and high-density CAC. |
| first_indexed | 2024-03-10T04:20:09Z |
| format | Article |
| id | doaj.art-96fc6148a9b54e7b89104bd32dc90c37 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:20:09Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-96fc6148a9b54e7b89104bd32dc90c372023-11-23T07:52:41ZengMDPI AGDiagnostics2075-44182021-11-011112219210.3390/diagnostics11122192Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom StudyNiels R. van der Werf0Margo van Gent1Ronald Booij2Daniel Bos3Aad van der Lugt4Ricardo P. J. Budde5Marcel J. W. Greuter6Marcel van Straten7Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsIn order to assess coronary artery calcium (CAC) quantification reproducibility for photon-counting computed tomography (PCCT) at reduced tube potential, an anthropomorphic thorax phantom with low-, medium-, and high-density CAC inserts was scanned with PCCT (NAEOTOM Alpha, Siemens Healthineers) at two heart rates: 0 and 60–75 beats per minute (bpm). Five imaging protocols were used: 120 kVp standard dose (IQ level 16, reference), 90 kVp at standard (IQ level 16), 75% and 45% dose and tin-filtered 100 kVp at standard dose (IQ level 16). Each scan was repeated five times. Images were reconstructed using monoE reconstruction at 70 keV. For each heart rate, CAC values, quantified as Agatston scores, were compared with the reference, whereby deviations >10% were deemed clinically relevant. Reference protocol radiation dose (as volumetric CT dose index) was 4.06 mGy. Radiation dose was reduced by 27%, 44%, 67%, and 46% for the 90 kVp standard dose, 90 kVp 75% dose, 90 kVp 45% dose, and Sn100 standard dose protocol, respectively. For the low-density CAC, all reduced tube current protocols resulted in clinically relevant differences with the reference. For the medium- and high-density CAC, the implemented 90 kVp protocols and heart rates revealed no clinically relevant differences in Agatston score based on 95% confidence intervals. In conclusion, PCCT allows for reproducible Agatston scores at a reduced tube voltage of 90 kVp with radiation dose reductions up to 67% for medium- and high-density CAC.https://www.mdpi.com/2075-4418/11/12/2192X-ray computed tomographycalciumcoronary vesselsimaging phantomsphoton counting detectorradiation dose |
| spellingShingle | Niels R. van der Werf Margo van Gent Ronald Booij Daniel Bos Aad van der Lugt Ricardo P. J. Budde Marcel J. W. Greuter Marcel van Straten Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study Diagnostics X-ray computed tomography calcium coronary vessels imaging phantoms photon counting detector radiation dose |
| title | Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study |
| title_full | Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study |
| title_fullStr | Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study |
| title_full_unstemmed | Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study |
| title_short | Dose Reduction in Coronary Artery Calcium Scoring Using Mono-Energetic Images from Reduced Tube Voltage Dual-Source Photon-Counting CT Data: A Dynamic Phantom Study |
| title_sort | dose reduction in coronary artery calcium scoring using mono energetic images from reduced tube voltage dual source photon counting ct data a dynamic phantom study |
| topic | X-ray computed tomography calcium coronary vessels imaging phantoms photon counting detector radiation dose |
| url | https://www.mdpi.com/2075-4418/11/12/2192 |
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