A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells

A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells

Modeling interactions between primary human hepatocytes (PHHs) and primary human liver sinusoidal endothelial cells (LSECs) in vitro can help elucidate human-specific mechanisms underlying liver physiology/disease and drug responses; however, existing hepatocyte/endothelial coculture models are subo...

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Bibliographic Details
Main Authors: Brenton R. Ware, Mitchell J. Durham, Chase P. Monckton, Salman R. Khetani
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Micropatterned Cocultures
Tricultures
LSECs
HUVECs
3T3-J2 Fibroblasts
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301625

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