Body composition, lifestyle, and depression: a prospective study in the UK biobank
Abstract Background Obesity has been related to depression and adhering healthy lifestyle was beneficial to lower the risk of depression; however, little is known about the relationship between body composition and fat distribution with depression risk and the influence of body composition and fat d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-17891-6 |
| _version_ | 1797272909565132800 |
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| author | Xingyu Lv Jie Cai Xiang Li Xuan Wang Hao Ma Yoriko Heianza Lu Qi Tao Zhou |
| author_facet | Xingyu Lv Jie Cai Xiang Li Xuan Wang Hao Ma Yoriko Heianza Lu Qi Tao Zhou |
| author_sort | Xingyu Lv |
| collection | DOAJ |
| description | Abstract Background Obesity has been related to depression and adhering healthy lifestyle was beneficial to lower the risk of depression; however, little is known about the relationship between body composition and fat distribution with depression risk and the influence of body composition and fat distribution on the association of lifestyle and depression. Therefore, we aimed to investigate whether body composition and fat distribution were associated with the adverse events of depression and the relationship between lifestyle and depression. Methods We included 330,131 participants without depression at baseline in the UK Biobank (mean age, 56.9 years; 53.83% females). The assessment of depression was sourced from health outcomes across self-report, primary care, hospital inpatient data, and death data. Body composition was determined by bioelectrical impedance. Seven lifestyles (no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, less sedentary behavior, healthy sleep pattern, and appropriate social connection) were used to generate a lifestyle score. Results During a median of 11.7 years of follow-up, 7576 incident depression occurred. All the body composition measures were positively associated with depression risk, with the Hazard ratios (HR) for the uppermost tertile (T3) versus the lowest tertile (T1) ranging from 1.26 (95% CI: 1.15–1.39) for trunk fat-free mass (TFFM) to 1.78 (1.62–1.97) for leg fat percentage (LFP). In addition, we found significant interactions between fat mass-related indices, especially leg fat mass (LFM) (p = 1.65 × 10−9), and lifestyle score on the risk of depression, for which the beneficial associations of a healthy lifestyle with the risk of depression were more evident among participants with low body fat measurement. Conclusions High levels of body composition measures were associated with an increased depression risk. Adverse body composition measures may weaken the link between a healthy lifestyle and a reduced risk of depression. |
| first_indexed | 2024-03-07T14:37:03Z |
| format | Article |
| id | doaj.art-96fe90f363bb45d9b61a58fa4708730f |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-07T14:37:03Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-96fe90f363bb45d9b61a58fa4708730f2024-03-05T20:37:13ZengBMCBMC Public Health1471-24582024-02-0124111010.1186/s12889-024-17891-6Body composition, lifestyle, and depression: a prospective study in the UK biobankXingyu Lv0Jie Cai1Xiang Li2Xuan Wang3Hao Ma4Yoriko Heianza5Lu Qi6Tao Zhou7Department of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen UniversityDepartment of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen UniversityDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane UniversityDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane UniversityDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane UniversityDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane UniversityDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane UniversityDepartment of Epidemiology, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen UniversityAbstract Background Obesity has been related to depression and adhering healthy lifestyle was beneficial to lower the risk of depression; however, little is known about the relationship between body composition and fat distribution with depression risk and the influence of body composition and fat distribution on the association of lifestyle and depression. Therefore, we aimed to investigate whether body composition and fat distribution were associated with the adverse events of depression and the relationship between lifestyle and depression. Methods We included 330,131 participants without depression at baseline in the UK Biobank (mean age, 56.9 years; 53.83% females). The assessment of depression was sourced from health outcomes across self-report, primary care, hospital inpatient data, and death data. Body composition was determined by bioelectrical impedance. Seven lifestyles (no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, less sedentary behavior, healthy sleep pattern, and appropriate social connection) were used to generate a lifestyle score. Results During a median of 11.7 years of follow-up, 7576 incident depression occurred. All the body composition measures were positively associated with depression risk, with the Hazard ratios (HR) for the uppermost tertile (T3) versus the lowest tertile (T1) ranging from 1.26 (95% CI: 1.15–1.39) for trunk fat-free mass (TFFM) to 1.78 (1.62–1.97) for leg fat percentage (LFP). In addition, we found significant interactions between fat mass-related indices, especially leg fat mass (LFM) (p = 1.65 × 10−9), and lifestyle score on the risk of depression, for which the beneficial associations of a healthy lifestyle with the risk of depression were more evident among participants with low body fat measurement. Conclusions High levels of body composition measures were associated with an increased depression risk. Adverse body composition measures may weaken the link between a healthy lifestyle and a reduced risk of depression.https://doi.org/10.1186/s12889-024-17891-6Fat distributionMental healthMetabolismEpidemiology |
| spellingShingle | Xingyu Lv Jie Cai Xiang Li Xuan Wang Hao Ma Yoriko Heianza Lu Qi Tao Zhou Body composition, lifestyle, and depression: a prospective study in the UK biobank BMC Public Health Fat distribution Mental health Metabolism Epidemiology |
| title | Body composition, lifestyle, and depression: a prospective study in the UK biobank |
| title_full | Body composition, lifestyle, and depression: a prospective study in the UK biobank |
| title_fullStr | Body composition, lifestyle, and depression: a prospective study in the UK biobank |
| title_full_unstemmed | Body composition, lifestyle, and depression: a prospective study in the UK biobank |
| title_short | Body composition, lifestyle, and depression: a prospective study in the UK biobank |
| title_sort | body composition lifestyle and depression a prospective study in the uk biobank |
| topic | Fat distribution Mental health Metabolism Epidemiology |
| url | https://doi.org/10.1186/s12889-024-17891-6 |
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