A network view on Schizophrenia related genes
This study is a part of a project investigating the molecular determinants of neurological diseases. To account for the systemic nature of these diseases we proceeded from a well established list of 38 schizophrenia-related genes (Allen et al., 2008; Ross et al., 2006) and investigated their closest...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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International Academy of Ecology and Environmental Sciences
2012-03-01
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| Series: | Network Biology |
| Subjects: | |
| Online Access: | http://www.iaees.org/publications/journals/nb/articles/2012-2(1)/network-view-on-Schizophrenia-related-genes.pdf |
| _version_ | 1819052359345504256 |
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| author | Sreedevi Chandrasekaran Danail G. Bonchev |
| author_facet | Sreedevi Chandrasekaran Danail G. Bonchev |
| author_sort | Sreedevi Chandrasekaran |
| collection | DOAJ |
| description | This study is a part of a project investigating the molecular determinants of neurological diseases. To account for the systemic nature of these diseases we proceeded from a well established list of 38 schizophrenia-related genes (Allen et al., 2008; Ross et al., 2006) and investigated their closest network environment. The created networks were compared to recently proposed list of 173 schizophrenia related genes (Sun et al., 2009). 115 genes were predicted as potentially related to schizophrenia and subjected to GSEA. The enriched groups of proteins included neuromodulators, neurotransmitters and lipid transport. Over 100 signaling pathways were found significantly involved, signal transduction emerging as the most highly significant biological process. Next, we analyzed two microarray expression datasets derived from olfactory mucosa biopsies of schizophrenic patients and postmortem brain tissue samples from SMRIDB. The systems biology analysis resulted in a number of other genes predicted to be potentially related to schizophrenia, as well as in additional information of interest for elucidating molecular mechanisms of schizophrenia. |
| first_indexed | 2024-12-21T12:18:35Z |
| format | Article |
| id | doaj.art-96feb5f76dc64997bc6618c8e526de1a |
| institution | Directory Open Access Journal |
| issn | 2220-8879 |
| language | English |
| last_indexed | 2024-12-21T12:18:35Z |
| publishDate | 2012-03-01 |
| publisher | International Academy of Ecology and Environmental Sciences |
| record_format | Article |
| series | Network Biology |
| spelling | doaj.art-96feb5f76dc64997bc6618c8e526de1a2022-12-21T19:04:22ZengInternational Academy of Ecology and Environmental SciencesNetwork Biology2220-88792012-03-01211625A network view on Schizophrenia related genesSreedevi ChandrasekaranDanail G. BonchevThis study is a part of a project investigating the molecular determinants of neurological diseases. To account for the systemic nature of these diseases we proceeded from a well established list of 38 schizophrenia-related genes (Allen et al., 2008; Ross et al., 2006) and investigated their closest network environment. The created networks were compared to recently proposed list of 173 schizophrenia related genes (Sun et al., 2009). 115 genes were predicted as potentially related to schizophrenia and subjected to GSEA. The enriched groups of proteins included neuromodulators, neurotransmitters and lipid transport. Over 100 signaling pathways were found significantly involved, signal transduction emerging as the most highly significant biological process. Next, we analyzed two microarray expression datasets derived from olfactory mucosa biopsies of schizophrenic patients and postmortem brain tissue samples from SMRIDB. The systems biology analysis resulted in a number of other genes predicted to be potentially related to schizophrenia, as well as in additional information of interest for elucidating molecular mechanisms of schizophrenia.http://www.iaees.org/publications/journals/nb/articles/2012-2(1)/network-view-on-Schizophrenia-related-genes.pdfSchizophrenianetwork analysismicroarray expression data |
| spellingShingle | Sreedevi Chandrasekaran Danail G. Bonchev A network view on Schizophrenia related genes Network Biology Schizophrenia network analysis microarray expression data |
| title | A network view on Schizophrenia related genes |
| title_full | A network view on Schizophrenia related genes |
| title_fullStr | A network view on Schizophrenia related genes |
| title_full_unstemmed | A network view on Schizophrenia related genes |
| title_short | A network view on Schizophrenia related genes |
| title_sort | network view on schizophrenia related genes |
| topic | Schizophrenia network analysis microarray expression data |
| url | http://www.iaees.org/publications/journals/nb/articles/2012-2(1)/network-view-on-Schizophrenia-related-genes.pdf |
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