Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-11-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-020-00723-1 |
| _version_ | 1798039002301857792 |
|---|---|
| author | Xiao-ge Liu Lun Zhang Shuai Lu Dong-qun Liu Ya-ru Huang Jie Zhu Wei-wei Zhou Xiao-lin Yu Rui-tian Liu |
| author_facet | Xiao-ge Liu Lun Zhang Shuai Lu Dong-qun Liu Ya-ru Huang Jie Zhu Wei-wei Zhou Xiao-lin Yu Rui-tian Liu |
| author_sort | Xiao-ge Liu |
| collection | DOAJ |
| description | Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment. Results We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. Conclusion These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention. |
| first_indexed | 2024-04-11T21:47:55Z |
| format | Article |
| id | doaj.art-96ff639954c94c9cba334d83b238166b |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T21:47:55Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-96ff639954c94c9cba334d83b238166b2022-12-22T04:01:21ZengBMCJournal of Nanobiotechnology1477-31552020-11-0118111310.1186/s12951-020-00723-1Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s DiseaseXiao-ge Liu0Lun Zhang1Shuai Lu2Dong-qun Liu3Ya-ru Huang4Jie Zhu5Wei-wei Zhou6Xiao-lin Yu7Rui-tian Liu8State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of SciencesAbstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment. Results We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. Conclusion These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.http://link.springer.com/article/10.1186/s12951-020-00723-1Alzheimer’s diseaseβ-AmyloidOligomerClass A scavenger receptorTherapy |
| spellingShingle | Xiao-ge Liu Lun Zhang Shuai Lu Dong-qun Liu Ya-ru Huang Jie Zhu Wei-wei Zhou Xiao-lin Yu Rui-tian Liu Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease Journal of Nanobiotechnology Alzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy |
| title | Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease |
| title_full | Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease |
| title_fullStr | Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease |
| title_full_unstemmed | Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease |
| title_short | Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease |
| title_sort | superparamagnetic iron oxide nanoparticles conjugated with aβ oligomer specific scfv antibody and class a scavenger receptor activator show therapeutic potentials for alzheimer s disease |
| topic | Alzheimer’s disease β-Amyloid Oligomer Class A scavenger receptor Therapy |
| url | http://link.springer.com/article/10.1186/s12951-020-00723-1 |
| work_keys_str_mv | AT xiaogeliu superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT lunzhang superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT shuailu superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT dongqunliu superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT yaruhuang superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT jiezhu superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT weiweizhou superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT xiaolinyu superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease AT ruitianliu superparamagneticironoxidenanoparticlesconjugatedwithaboligomerspecificscfvantibodyandclassascavengerreceptoractivatorshowtherapeuticpotentialsforalzheimersdisease |