Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches...

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Bibliographic Details
Main Authors: Xiao-ge Liu, Lun Zhang, Shuai Lu, Dong-qun Liu, Ya-ru Huang, Jie Zhu, Wei-wei Zhou, Xiao-lin Yu, Rui-tian Liu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Nanobiotechnology
Subjects:
Alzheimer’s disease
β-Amyloid
Oligomer
Class A scavenger receptor
Therapy
Online Access:http://link.springer.com/article/10.1186/s12951-020-00723-1

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