Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3)
The difficulties in the diagnosis of invasive fungal disease (IFD) in hematological malignancies and the proper use of the diagnostic tests are among the important problems the clinician face. Although, the defi nitions of IFD from the European Organization for Research and Treatment of Cancer (EORT...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2015-09-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2015-20-03-111-119.pdf |
| _version_ | 1797907832599740416 |
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| author | Alpay AZAP Sibel AŞÇIOĞLU HAYRAN Özlem ÖZDEMİR KUMBASAR Ömrüm UZUN Sevtap ARIKAN AKDAĞLI Figen BAŞARAN DEMİRKAZIK Beyza ENER Gökhan METAN Zekaver ODABAŞI Hamdi AKAN |
| author_facet | Alpay AZAP Sibel AŞÇIOĞLU HAYRAN Özlem ÖZDEMİR KUMBASAR Ömrüm UZUN Sevtap ARIKAN AKDAĞLI Figen BAŞARAN DEMİRKAZIK Beyza ENER Gökhan METAN Zekaver ODABAŞI Hamdi AKAN |
| author_sort | Alpay AZAP |
| collection | DOAJ |
| description | The difficulties in the diagnosis of invasive fungal disease (IFD) in hematological malignancies and the proper use of the diagnostic tests are among the important problems the clinician face. Although, the defi nitions of IFD from the European Organization for Research and Treatment of Cancer (EORTC) and Mycosis Study Group (MSG) are aimed to standardize the subject, these are only for clinical research. Especially, the diffi culty of mycological diagnosis and the necessity of immediate intervention in molds have led to the adoption of “surrogate markers” which does not verify, but strongly suggests fungal infection. The markers commonly used are galactomannan
(GM), beta-glucan and imaging methods. Although there are numerous studies on these diagnostic approaches, none of these markers serve as a support for the clinician, as is in human immunodefi ciency virus (HIV) or cytomegalovirus (CMV) infections. Clinician has an important role in diagnosis and he/she have to make the correct decision by corroborating these diagnostic tools with clinical state of the patient and the available epidemiological data.This paper has been prepared to show the clinician how the available resources can be used. As molecular tests have not been standardized and not used routinely in the clinics, they will not be mentioned here. |
| first_indexed | 2024-04-10T10:43:25Z |
| format | Article |
| id | doaj.art-97013d6caaa24d878934555aa7cbda9a |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T10:43:25Z |
| publishDate | 2015-09-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-97013d6caaa24d878934555aa7cbda9a2023-02-15T16:20:27ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2015-09-01203111119Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3)Alpay AZAP0Sibel AŞÇIOĞLU HAYRAN1Özlem ÖZDEMİR KUMBASAR2Ömrüm UZUN3Sevtap ARIKAN AKDAĞLI4Figen BAŞARAN DEMİRKAZIK5Beyza ENER6Gökhan METAN7Zekaver ODABAŞI8Hamdi AKAN9Department of Infectious Diseases and Clinical Microbiology, Ibni Sina Hospital, Faculty of Medicine, University of Ankara, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Hacettepe, Ankara, TurkeyDepartment of Chest Diseases, Faculty of Medicine, University of Ankara, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Hacettepe, Ankara, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, University of Hacettepe, Ankara, TurkeyDepartment of Radiology, Faculty of Medicine, University of Hacettepe, Ankara, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, University of Uludag, Bursa, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Erciyes, Kayseri, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Marmara, Istanbul, TurkeyDivision of Hematology, Faculty of Medicine, University of Ankara, Ankara, TurkeyThe difficulties in the diagnosis of invasive fungal disease (IFD) in hematological malignancies and the proper use of the diagnostic tests are among the important problems the clinician face. Although, the defi nitions of IFD from the European Organization for Research and Treatment of Cancer (EORTC) and Mycosis Study Group (MSG) are aimed to standardize the subject, these are only for clinical research. Especially, the diffi culty of mycological diagnosis and the necessity of immediate intervention in molds have led to the adoption of “surrogate markers” which does not verify, but strongly suggests fungal infection. The markers commonly used are galactomannan (GM), beta-glucan and imaging methods. Although there are numerous studies on these diagnostic approaches, none of these markers serve as a support for the clinician, as is in human immunodefi ciency virus (HIV) or cytomegalovirus (CMV) infections. Clinician has an important role in diagnosis and he/she have to make the correct decision by corroborating these diagnostic tools with clinical state of the patient and the available epidemiological data.This paper has been prepared to show the clinician how the available resources can be used. As molecular tests have not been standardized and not used routinely in the clinics, they will not be mentioned here.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2015-20-03-111-119.pdfDiagnosisInvasive fungal infectionImagingSerologyEORTC-MSG |
| spellingShingle | Alpay AZAP Sibel AŞÇIOĞLU HAYRAN Özlem ÖZDEMİR KUMBASAR Ömrüm UZUN Sevtap ARIKAN AKDAĞLI Figen BAŞARAN DEMİRKAZIK Beyza ENER Gökhan METAN Zekaver ODABAŞI Hamdi AKAN Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3) Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Diagnosis Invasive fungal infection Imaging Serology EORTC-MSG |
| title | Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3) |
| title_full | Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3) |
| title_fullStr | Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3) |
| title_full_unstemmed | Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3) |
| title_short | Recommendations for the Clinical Use of Diagnostic Tools in Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-3) |
| title_sort | recommendations for the clinical use of diagnostic tools in invasive fungal diseases in hematological malignancies a critical review of evidence and turkish expert opinion teo 3 |
| topic | Diagnosis Invasive fungal infection Imaging Serology EORTC-MSG |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2015-20-03-111-119.pdf |
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