Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

Objective: The endocannabinoid (eCB) system is increasingly recognized as being crucially important in obesity-related hepatic steatosis. By activating the hepatic cannabinoid-1 receptor (CB1R), eCBs modulate lipogenesis and fatty acid oxidation. However, the underlying molecular mechanisms are larg...

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Bibliographic Details
Main Authors: Shahar Azar, Shiran Udi, Adi Drori, Rivka Hadar, Alina Nemirovski, Kiran V. Vemuri, Maya Miller, Dana Sherill-Rofe, Yhara Arad, Devorah Gur-Wahnon, Xiaoling Li, Alexandros Makriyannis, Danny Ben-Zvi, Yuval Tabach, Iddo Z. Ben-Dov, Joseph Tam
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
Obesity
Fatty liver
Endocannabinoids
microRNAs
Nuclear receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301617

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