Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders
We examined the associations between metabolic syndrome (MetS) and neurocognitive function in patients with first-episode schizophrenia spectrum disorders (FES) compared to controls assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. In patients, psychopathology wa...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Psychiatry Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772598724000126 |
| _version_ | 1797242964905295872 |
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| author | H.K. Luckhoff S. Suliman L. van den Heuvel R. Smit S. Kilian E. Bröcker Lebogang Phaladira L. Asmal S. Seedat R. Emsley |
| author_facet | H.K. Luckhoff S. Suliman L. van den Heuvel R. Smit S. Kilian E. Bröcker Lebogang Phaladira L. Asmal S. Seedat R. Emsley |
| author_sort | H.K. Luckhoff |
| collection | DOAJ |
| description | We examined the associations between metabolic syndrome (MetS) and neurocognitive function in patients with first-episode schizophrenia spectrum disorders (FES) compared to controls assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. In patients, psychopathology was assessed using the Positive and Negative Syndrome Scale and Calgary Depression Scale for Schizophrenia. First, we found illness- and domain-specific associations between the individual MetS features and neurocognitive performance in patients, but not in controls. Second, body mass index and total cholesterol levels were lower in patients than controls, which in turn correlated with increased global psychopathology severity and cognitive deficits. Third, negative symptoms moderated the association between low HDL cholesterol and poorer immediate verbal memory performance in patients. Our findings suggest that distinct lipid profile alterations are associated with cognitive performance and psychopathology severity in patients with FES. Further studies are needed to explore the associations of MetS with neurocognition over time, as well as how these relationships are affected by socio-demographic and clinical factors, including depression, anxiety, and related psychopathology. |
| first_indexed | 2024-04-24T18:47:35Z |
| format | Article |
| id | doaj.art-9702067302bd46a3a8f16c469f5a24ff |
| institution | Directory Open Access Journal |
| issn | 2772-5987 |
| language | English |
| last_indexed | 2024-04-24T18:47:35Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Psychiatry Research Communications |
| spelling | doaj.art-9702067302bd46a3a8f16c469f5a24ff2024-03-27T04:53:17ZengElsevierPsychiatry Research Communications2772-59872024-06-0142100166Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disordersH.K. Luckhoff0S. Suliman1L. van den Heuvel2R. Smit3S. Kilian4E. Bröcker5Lebogang Phaladira6L. Asmal7S. Seedat8R. Emsley9Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South Africa; Corresponding author.Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South Africa; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Extramural Research Unit, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaSouth African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Extramural Research Unit, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South Africa; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Extramural Research Unit, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South Africa; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Extramural Research Unit, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7550, South AfricaWe examined the associations between metabolic syndrome (MetS) and neurocognitive function in patients with first-episode schizophrenia spectrum disorders (FES) compared to controls assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. In patients, psychopathology was assessed using the Positive and Negative Syndrome Scale and Calgary Depression Scale for Schizophrenia. First, we found illness- and domain-specific associations between the individual MetS features and neurocognitive performance in patients, but not in controls. Second, body mass index and total cholesterol levels were lower in patients than controls, which in turn correlated with increased global psychopathology severity and cognitive deficits. Third, negative symptoms moderated the association between low HDL cholesterol and poorer immediate verbal memory performance in patients. Our findings suggest that distinct lipid profile alterations are associated with cognitive performance and psychopathology severity in patients with FES. Further studies are needed to explore the associations of MetS with neurocognition over time, as well as how these relationships are affected by socio-demographic and clinical factors, including depression, anxiety, and related psychopathology.http://www.sciencedirect.com/science/article/pii/S2772598724000126SchizophreniaMetabolic syndromeHDL cholesterolCognitionImmediate verbal memory |
| spellingShingle | H.K. Luckhoff S. Suliman L. van den Heuvel R. Smit S. Kilian E. Bröcker Lebogang Phaladira L. Asmal S. Seedat R. Emsley Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders Psychiatry Research Communications Schizophrenia Metabolic syndrome HDL cholesterol Cognition Immediate verbal memory |
| title | Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders |
| title_full | Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders |
| title_fullStr | Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders |
| title_full_unstemmed | Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders |
| title_short | Metabolic syndrome associations with neurocognitive function in first-episode schizophrenia spectrum disorders |
| title_sort | metabolic syndrome associations with neurocognitive function in first episode schizophrenia spectrum disorders |
| topic | Schizophrenia Metabolic syndrome HDL cholesterol Cognition Immediate verbal memory |
| url | http://www.sciencedirect.com/science/article/pii/S2772598724000126 |
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