The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients
• Background: Peritonitis is the most important complication of peritoneal dialysis. The most common cause of peritonitis is catheter exit site infection. Several studies have shown the prophylactic effect of topical mupirocin. According to the report of drug resistance in several studies to muproci...
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| Format: | Article |
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Isfahan University of Medical Sciences
2011-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/719 |
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| author | Mojgan Mortazavi Mehran Halabian Shiva Seirafian Afsoon Emami Ziba Farajzadegan Firoozeh Moinzadeh Shirin Karimi |
| author_facet | Mojgan Mortazavi Mehran Halabian Shiva Seirafian Afsoon Emami Ziba Farajzadegan Firoozeh Moinzadeh Shirin Karimi |
| author_sort | Mojgan Mortazavi |
| collection | DOAJ |
| description | • Background: Peritonitis is the most important complication of peritoneal dialysis. The most common cause of peritonitis is catheter exit site infection. Several studies have shown the prophylactic effect of topical mupirocin. According to the report of drug resistance in several studies to muprocin and exit site infection with gram-negative organisms, this study compared the prophylacyic effect of gentamicin with muprocin.
• Methods: This double blind clinical trial was done on 121 peritoneal dialysis patients. We have investigated the frequency of peritonitis and exit site infection in 2 groups receiving gentamicin and mupirocin ointment for 6 months. Data were analyzed by SPSS software using Student-t, chi-square and logistic regression tests.
• Finding: After six months, 8 cases of peritonitis were reported in gentamicin group compared to no cases in mupirocin group (P = 0.03). The exit site infection in the fourth and fifth months in the gentamicin group compared to mupirocin group was respectively 4.2 and 3.3 times (P = 0.0001).
• Conclusion: According to the results of this study, gentamicin ointment have not shown a prophylactic effect on the incidence of exit site infection and peritonitis compared with mupirocin ointment and it is not recommended as a substitute. |
| first_indexed | 2024-03-12T08:59:53Z |
| format | Article |
| id | doaj.art-97025f93d2794cfa9b55820b1ccf9da7 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:59:53Z |
| publishDate | 2011-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-97025f93d2794cfa9b55820b1ccf9da72023-09-02T15:45:44ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2011-03-012811610621069502The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis PatientsMojgan Mortazavi0Mehran Halabian1Shiva Seirafian2Afsoon Emami3Ziba Farajzadegan4Firoozeh Moinzadeh5Shirin Karimi6Isfahan Kidney Diseases Research Center, Assistant Professor, Department of Nephrology, School of Medicine ,Isfahan University of Medical Sciences, Isfahan, Iran.Nephrology Resident, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Isfahan Kidney Diseases Research Center, Associate Professor, Department of Nephrology, School of Medicine ,Isfahan University of Medical Sciences, Isfahan, Iran.Isfahan Kidney Diseases Research Center, Associate Professor, Department of Nephrology, School of Medicine ,Isfahan University of Medical Sciences, Isfahan, Iran.Associate Professor, Department of Social Medicine, School of Medicine ,Isfahan University of Medical Sciences, Isfahan, Iran.Internal Medicine Resident, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Nurse, Peritoneal Dialysis, Alzahra Hospital, Isfahan, Iran.• Background: Peritonitis is the most important complication of peritoneal dialysis. The most common cause of peritonitis is catheter exit site infection. Several studies have shown the prophylactic effect of topical mupirocin. According to the report of drug resistance in several studies to muprocin and exit site infection with gram-negative organisms, this study compared the prophylacyic effect of gentamicin with muprocin. • Methods: This double blind clinical trial was done on 121 peritoneal dialysis patients. We have investigated the frequency of peritonitis and exit site infection in 2 groups receiving gentamicin and mupirocin ointment for 6 months. Data were analyzed by SPSS software using Student-t, chi-square and logistic regression tests. • Finding: After six months, 8 cases of peritonitis were reported in gentamicin group compared to no cases in mupirocin group (P = 0.03). The exit site infection in the fourth and fifth months in the gentamicin group compared to mupirocin group was respectively 4.2 and 3.3 times (P = 0.0001). • Conclusion: According to the results of this study, gentamicin ointment have not shown a prophylactic effect on the incidence of exit site infection and peritonitis compared with mupirocin ointment and it is not recommended as a substitute.http://jims.mui.ac.ir/index.php/jims/article/view/719Peritoneal dialysisPeritonitisExit site infectionGentamicin ointmentMupirocin ointment |
| spellingShingle | Mojgan Mortazavi Mehran Halabian Shiva Seirafian Afsoon Emami Ziba Farajzadegan Firoozeh Moinzadeh Shirin Karimi The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients مجله دانشکده پزشکی اصفهان Peritoneal dialysis Peritonitis Exit site infection Gentamicin ointment Mupirocin ointment |
| title | The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients |
| title_full | The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients |
| title_fullStr | The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients |
| title_full_unstemmed | The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients |
| title_short | The Effect of Topical Gentamicin and Mupirocin on Peritonitis and Exit Site Infection in Peritoneal Dialysis Patients |
| title_sort | effect of topical gentamicin and mupirocin on peritonitis and exit site infection in peritoneal dialysis patients |
| topic | Peritoneal dialysis Peritonitis Exit site infection Gentamicin ointment Mupirocin ointment |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/719 |
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