The microecological status of candidates for liver transplantation
A method for identifying mixed infections, dysbioses, and inflammatory processes from specific markers (fatty acids, aldehydes, and sterols) by chromatographic mass spectrometry was used to study the microecological status of patients eligible for liver transplantation. Heterogeneous microorganisms...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/267 |
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| author | V. V. Kiselev O. I. Andreitseva N. B. Boiko G. A. Osipov N. F. Fedosova K. V. Lyadov |
| author_facet | V. V. Kiselev O. I. Andreitseva N. B. Boiko G. A. Osipov N. F. Fedosova K. V. Lyadov |
| author_sort | V. V. Kiselev |
| collection | DOAJ |
| description | A method for identifying mixed infections, dysbioses, and inflammatory processes from specific markers (fatty acids, aldehydes, and sterols) by chromatographic mass spectrometry was used to study the microecological status of patients eligible for liver transplantation. Heterogeneous microorganisms (aerobes, anaerobes, actinobacteria, fungi, and viruses) were quantified from molecular markers in an experiment within 3 hours after the samples were sent to the laboratory. The examinees were found to have excessive growth of gram-positive anaerobes (Clostridia, eubacteria), actinobacteria of the genera Streptomyces, Nocardia, and Candida yeasts. Next were staphylococci, streptococci, and gram-negative microorganisms of the group Moraxella/Acinetobacter, Pseudomonas aeruginosa, Helicobacter pylory, and Fusobacterium/Haemophylus. Antibiotics and probiotics were chosen to correct dysbiosis and infection, by taking into account the data available in the literature. The speed and accuracy of the procedure ensure real-time monitoring of a treatment process under control of mass spectrometry. |
| first_indexed | 2024-03-12T18:42:54Z |
| format | Article |
| id | doaj.art-970317bb3d7b4cf6a0167084276ddb1b |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2024-03-12T18:42:54Z |
| publishDate | 2018-08-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-970317bb3d7b4cf6a0167084276ddb1b2023-08-02T07:48:45ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092018-08-0101374510.23873/2074-0506-2010-0-1-37-45256The microecological status of candidates for liver transplantationV. V. Kiselev0O. I. Andreitseva1N. B. Boiko2G. A. Osipov3N. F. Fedosova4K. V. Lyadov5НИИ скорой помощи им. Н.В. СклифосовскогоНИИ скорой помощи им. Н.В. СклифосовскогоАкадемическая группа акад. РАМН Ю.Ф. Исакова (при НЦССХ им. А.Н.Бакулева)Академическая группа акад. РАМН Ю.Ф. Исакова (при НЦССХ им. А.Н.Бакулева)Лечебно-реабилитационный центр Росздрава РФЛечебно-реабилитационный центр Росздрава РФA method for identifying mixed infections, dysbioses, and inflammatory processes from specific markers (fatty acids, aldehydes, and sterols) by chromatographic mass spectrometry was used to study the microecological status of patients eligible for liver transplantation. Heterogeneous microorganisms (aerobes, anaerobes, actinobacteria, fungi, and viruses) were quantified from molecular markers in an experiment within 3 hours after the samples were sent to the laboratory. The examinees were found to have excessive growth of gram-positive anaerobes (Clostridia, eubacteria), actinobacteria of the genera Streptomyces, Nocardia, and Candida yeasts. Next were staphylococci, streptococci, and gram-negative microorganisms of the group Moraxella/Acinetobacter, Pseudomonas aeruginosa, Helicobacter pylory, and Fusobacterium/Haemophylus. Antibiotics and probiotics were chosen to correct dysbiosis and infection, by taking into account the data available in the literature. The speed and accuracy of the procedure ensure real-time monitoring of a treatment process under control of mass spectrometry.https://www.jtransplantologiya.ru/jour/article/view/267трансплантация печенимикроэкологиядисбактериоз газовая хроматографиямасс-спектрометрияжирные кислотымикробные маркерыанаэробная инфекцияклостридииэубактерии |
| spellingShingle | V. V. Kiselev O. I. Andreitseva N. B. Boiko G. A. Osipov N. F. Fedosova K. V. Lyadov The microecological status of candidates for liver transplantation Трансплантология (Москва) трансплантация печени микроэкология дисбактериоз газовая хроматография масс-спектрометрия жирные кислоты микробные маркеры анаэробная инфекция клостридии эубактерии |
| title | The microecological status of candidates for liver transplantation |
| title_full | The microecological status of candidates for liver transplantation |
| title_fullStr | The microecological status of candidates for liver transplantation |
| title_full_unstemmed | The microecological status of candidates for liver transplantation |
| title_short | The microecological status of candidates for liver transplantation |
| title_sort | microecological status of candidates for liver transplantation |
| topic | трансплантация печени микроэкология дисбактериоз газовая хроматография масс-спектрометрия жирные кислоты микробные маркеры анаэробная инфекция клостридии эубактерии |
| url | https://www.jtransplantologiya.ru/jour/article/view/267 |
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