Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diab...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04525-w |
| _version_ | 1818343412000096256 |
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| author | Jun Ishihara Ako Ishihara Kazuto Fukunaga Koichi Sasaki Michael J. V. White Priscilla S. Briquez Jeffrey A. Hubbell |
| author_facet | Jun Ishihara Ako Ishihara Kazuto Fukunaga Koichi Sasaki Michael J. V. White Priscilla S. Briquez Jeffrey A. Hubbell |
| author_sort | Jun Ishihara |
| collection | DOAJ |
| description | Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diabetic mouse models. |
| first_indexed | 2024-12-13T16:30:10Z |
| format | Article |
| id | doaj.art-970479756e7a4accbe4500ad2b9305a7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:30:10Z |
| publishDate | 2018-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-970479756e7a4accbe4500ad2b9305a72022-12-21T23:38:31ZengNature PortfolioNature Communications2041-17232018-06-019111410.1038/s41467-018-04525-wLaminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healingJun Ishihara0Ako Ishihara1Kazuto Fukunaga2Koichi Sasaki3Michael J. V. White4Priscilla S. Briquez5Jeffrey A. Hubbell6Institute for Molecular Engineering, University of ChicagoInstitute for Molecular Engineering, University of ChicagoInstitute for Molecular Engineering, University of ChicagoInstitute for Molecular Engineering, University of ChicagoInstitute for Molecular Engineering, University of ChicagoInstitute for Molecular Engineering, University of ChicagoInstitute for Molecular Engineering, University of ChicagoLaminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diabetic mouse models.https://doi.org/10.1038/s41467-018-04525-w |
| spellingShingle | Jun Ishihara Ako Ishihara Kazuto Fukunaga Koichi Sasaki Michael J. V. White Priscilla S. Briquez Jeffrey A. Hubbell Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing Nature Communications |
| title | Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing |
| title_full | Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing |
| title_fullStr | Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing |
| title_full_unstemmed | Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing |
| title_short | Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing |
| title_sort | laminin heparin binding peptides bind to several growth factors and enhance diabetic wound healing |
| url | https://doi.org/10.1038/s41467-018-04525-w |
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