Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data
The potential connection between proton pump inhibitors (PPIs) and colorectal cancer (CRC) risk remains unclear, with specific ethnic genetic backgrounds playing a role in PPI-induced adverse effects. In this nested case–control study, we investigated the risk of CRC in relation to preceding PPI use...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/23/5606 |
| _version_ | 1797400394431725568 |
|---|---|
| author | Mi Jung Kwon Kyeong Min Han Joo-Hee Kim Ji Hee Kim Min-Jeong Kim Nan Young Kim Hyo Geun Choi Ho Suk Kang |
| author_facet | Mi Jung Kwon Kyeong Min Han Joo-Hee Kim Ji Hee Kim Min-Jeong Kim Nan Young Kim Hyo Geun Choi Ho Suk Kang |
| author_sort | Mi Jung Kwon |
| collection | DOAJ |
| description | The potential connection between proton pump inhibitors (PPIs) and colorectal cancer (CRC) risk remains unclear, with specific ethnic genetic backgrounds playing a role in PPI-induced adverse effects. In this nested case–control study, we investigated the risk of CRC in relation to preceding PPI use and the duration of use using data from the Korean National Health Insurance Service–National Sample Cohort database, including 9374 incident CRC patients and 37,496 controls. To assess the impact of preceding PPI exposure (past vs. current) and use duration (days: <30, 30–90, and ≥90) on incident CRC, we conducted propensity score overlap-weighted multivariate logistic regression analyses, adjusted for confounding factors. Our findings revealed that past and current PPI users had an increased likelihood of developing CRC. Regardless of duration, individuals who used PPIs also had higher odds of developing CRC. Subgroup analyses revealed that CRC occurrence increased independent of history or duration of prior PPI use, consistent across various factors such as age, sex, income level, and residential area. These findings suggest that PPI use, regardless of past or present use and duration of use, may be related to an increased risk of developing CRC in the Korean population. |
| first_indexed | 2024-03-09T01:54:01Z |
| format | Article |
| id | doaj.art-9708c67e2cc04ab2bc4a94f6fe19de56 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:54:01Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9708c67e2cc04ab2bc4a94f6fe19de562023-12-08T15:12:41ZengMDPI AGCancers2072-66942023-11-011523560610.3390/cancers15235606Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance DataMi Jung Kwon0Kyeong Min Han1Joo-Hee Kim2Ji Hee Kim3Min-Jeong Kim4Nan Young Kim5Hyo Geun Choi6Ho Suk Kang7Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaHallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Neurosurgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaDepartment of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaHallym Institute of Translational Genomics and Bioinformatics, Hallym University Medical Center, Anyang 14068, Republic of KoreaSuseo Seoul E.N.T. Clinic and MD Analytics, Seoul 06349, Republic of KoreaDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of KoreaThe potential connection between proton pump inhibitors (PPIs) and colorectal cancer (CRC) risk remains unclear, with specific ethnic genetic backgrounds playing a role in PPI-induced adverse effects. In this nested case–control study, we investigated the risk of CRC in relation to preceding PPI use and the duration of use using data from the Korean National Health Insurance Service–National Sample Cohort database, including 9374 incident CRC patients and 37,496 controls. To assess the impact of preceding PPI exposure (past vs. current) and use duration (days: <30, 30–90, and ≥90) on incident CRC, we conducted propensity score overlap-weighted multivariate logistic regression analyses, adjusted for confounding factors. Our findings revealed that past and current PPI users had an increased likelihood of developing CRC. Regardless of duration, individuals who used PPIs also had higher odds of developing CRC. Subgroup analyses revealed that CRC occurrence increased independent of history or duration of prior PPI use, consistent across various factors such as age, sex, income level, and residential area. These findings suggest that PPI use, regardless of past or present use and duration of use, may be related to an increased risk of developing CRC in the Korean population.https://www.mdpi.com/2072-6694/15/23/5606colorectal cancerproton pump inhibitornational healthcare datanested case–control study |
| spellingShingle | Mi Jung Kwon Kyeong Min Han Joo-Hee Kim Ji Hee Kim Min-Jeong Kim Nan Young Kim Hyo Geun Choi Ho Suk Kang Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data Cancers colorectal cancer proton pump inhibitor national healthcare data nested case–control study |
| title | Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data |
| title_full | Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data |
| title_fullStr | Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data |
| title_full_unstemmed | Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data |
| title_short | Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data |
| title_sort | proton pump inhibitors and likelihood of colorectal cancer in the korean population insights from a nested case control study using national health insurance data |
| topic | colorectal cancer proton pump inhibitor national healthcare data nested case–control study |
| url | https://www.mdpi.com/2072-6694/15/23/5606 |
| work_keys_str_mv | AT mijungkwon protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT kyeongminhan protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT jooheekim protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT jiheekim protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT minjeongkim protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT nanyoungkim protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT hyogeunchoi protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata AT hosukkang protonpumpinhibitorsandlikelihoodofcolorectalcancerinthekoreanpopulationinsightsfromanestedcasecontrolstudyusingnationalhealthinsurancedata |