Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review
AbstractObjective To conduct a meta-analysis and systematic review on the association between anticholinergic medication uses and the risk of pneumonia in elderly adults.Materials and Methods Medical databases were searched included PubMed, Web of Science, EBSCO and Google Scholar (up to December 7,...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2209736 |
| _version_ | 1797353750345547776 |
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| author | Mindan Wu Zhixuan Li Wenchuan Zheng Jia Zhuang Shuhan Wu Qipeng Zhou Junfu Cai Houzhen Zheng Guixing Zeng Weilin Zhang Shengbin Zhang Maohuang Lin Xianyang Zhong Qichuan Zhang |
| author_facet | Mindan Wu Zhixuan Li Wenchuan Zheng Jia Zhuang Shuhan Wu Qipeng Zhou Junfu Cai Houzhen Zheng Guixing Zeng Weilin Zhang Shengbin Zhang Maohuang Lin Xianyang Zhong Qichuan Zhang |
| author_sort | Mindan Wu |
| collection | DOAJ |
| description | AbstractObjective To conduct a meta-analysis and systematic review on the association between anticholinergic medication uses and the risk of pneumonia in elderly adults.Materials and Methods Medical databases were searched included PubMed, Web of Science, EBSCO and Google Scholar (up to December 7, 2022). Studies evaluating association between anticholinergic medication uses and the risk of pneumonia in elderly adults were included. Studies without available data were excluded. We made meta-analysis by using adjusted odds ratio (aOR) with 95% confidence intervals (CIs) from random-effects model. The risk of bias was assessed using ROBINS-I tool and statistical heterogeneity using the I2 statistic. Registration: INPLASY202330070.Results A total of six studies with 107,012 participants were included. Meta-analysis results showed that anticholinergic medication uses was related with an increased risk of pneumonia (aOR = 1.59; 95%CI, 1.32–1.92) and stroke-associated pneumonia (aOR = 2.02; 95%CI, 1.76–2.33). Moreover, risk estimates of pneumonia for high-potency anticholinergics (aOR = 1.96; 95%CI, 1.22–3.14) were higher than those for low-potency anticholinergics (aOR = 1.58; 95%CI, 1.27–1.97). And increased risk of pneumonia was associated with the anticholinergic medication uses within 30 days (aOR = 2.13; 95%CI, 1.33–3.43), within 90 days (aOR = 2.03; 95%CI, 1.26–3.26) and chronic use (aOR = 1.65; 95%CI, 1.09–2.51).Conclusions The risk of pneumonia is increased in elderly adults with anticholinergic medication, especially with higher-potency anticholinergic drugs and in the initiation phase of anticholinergic medication. Clinicians should monitor their use in older patients carefully, especially when the pneumonia-related signs and symptoms are identified. |
| first_indexed | 2024-03-08T13:34:31Z |
| format | Article |
| id | doaj.art-9709f1e8967742f79ef6058214e6c315 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:34:31Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-9709f1e8967742f79ef6058214e6c3152024-01-16T19:13:22ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2209736Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic reviewMindan Wu0Zhixuan Li1Wenchuan Zheng2Jia Zhuang3Shuhan Wu4Qipeng Zhou5Junfu Cai6Houzhen Zheng7Guixing Zeng8Weilin Zhang9Shengbin Zhang10Maohuang Lin11Xianyang Zhong12Qichuan Zhang13Department of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaDepartment of Gastroenterology, Shantou Central Hospital, Shantou, ChinaDepartment of Pulmonary and Critical Care Medicine, Shantou Central Hospital, Shantou, ChinaAbstractObjective To conduct a meta-analysis and systematic review on the association between anticholinergic medication uses and the risk of pneumonia in elderly adults.Materials and Methods Medical databases were searched included PubMed, Web of Science, EBSCO and Google Scholar (up to December 7, 2022). Studies evaluating association between anticholinergic medication uses and the risk of pneumonia in elderly adults were included. Studies without available data were excluded. We made meta-analysis by using adjusted odds ratio (aOR) with 95% confidence intervals (CIs) from random-effects model. The risk of bias was assessed using ROBINS-I tool and statistical heterogeneity using the I2 statistic. Registration: INPLASY202330070.Results A total of six studies with 107,012 participants were included. Meta-analysis results showed that anticholinergic medication uses was related with an increased risk of pneumonia (aOR = 1.59; 95%CI, 1.32–1.92) and stroke-associated pneumonia (aOR = 2.02; 95%CI, 1.76–2.33). Moreover, risk estimates of pneumonia for high-potency anticholinergics (aOR = 1.96; 95%CI, 1.22–3.14) were higher than those for low-potency anticholinergics (aOR = 1.58; 95%CI, 1.27–1.97). And increased risk of pneumonia was associated with the anticholinergic medication uses within 30 days (aOR = 2.13; 95%CI, 1.33–3.43), within 90 days (aOR = 2.03; 95%CI, 1.26–3.26) and chronic use (aOR = 1.65; 95%CI, 1.09–2.51).Conclusions The risk of pneumonia is increased in elderly adults with anticholinergic medication, especially with higher-potency anticholinergic drugs and in the initiation phase of anticholinergic medication. Clinicians should monitor their use in older patients carefully, especially when the pneumonia-related signs and symptoms are identified.https://www.tandfonline.com/doi/10.1080/07853890.2023.2209736Anticholinergic medicationpneumoniaelderly adultsmeta-analysissystematic review |
| spellingShingle | Mindan Wu Zhixuan Li Wenchuan Zheng Jia Zhuang Shuhan Wu Qipeng Zhou Junfu Cai Houzhen Zheng Guixing Zeng Weilin Zhang Shengbin Zhang Maohuang Lin Xianyang Zhong Qichuan Zhang Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review Annals of Medicine Anticholinergic medication pneumonia elderly adults meta-analysis systematic review |
| title | Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review |
| title_full | Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review |
| title_fullStr | Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review |
| title_full_unstemmed | Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review |
| title_short | Association between anticholinergic medication uses and the risk of pneumonia in elderly adults: a meta-analysis and systematic review |
| title_sort | association between anticholinergic medication uses and the risk of pneumonia in elderly adults a meta analysis and systematic review |
| topic | Anticholinergic medication pneumonia elderly adults meta-analysis systematic review |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2209736 |
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