Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation
The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in the pathogenesis of stress-related psychiatric disorders. It is not well understood, however, how stress is represented at the neuronal level in the prefrontal cortical neuronal ensembles. Eve...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235228952200056X |
| _version_ | 1811271426988048384 |
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| author | Sachin Patel Keenan Johnson Danielle Adank Luis E. Rosas-Vidal |
| author_facet | Sachin Patel Keenan Johnson Danielle Adank Luis E. Rosas-Vidal |
| author_sort | Sachin Patel |
| collection | DOAJ |
| description | The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in the pathogenesis of stress-related psychiatric disorders. It is not well understood, however, how stress is represented at the neuronal level in the prefrontal cortical neuronal ensembles. Even less understood is how the representation of stress changes over time with repeated exposure. Here we show that the prelimbic prefrontal neuronal ensemble representation of foot shock stress exhibits rapid spatial drift within and between sessions. Despite this rapid spatial drift of the ensemble, the representation of the stressor itself stabilizes over days. Our results suggest that stress is represented by rapidly drifting ensembles and despite this rapid drift, important features of the neuronal representation are stabilized, suggesting a neural correlate of stress habituation is present within prefrontal cortical neuron populations. |
| first_indexed | 2024-04-12T22:20:53Z |
| format | Article |
| id | doaj.art-970c42e14b644a35bfa900373f39cec4 |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-04-12T22:20:53Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-970c42e14b644a35bfa900373f39cec42022-12-22T03:14:23ZengElsevierNeurobiology of Stress2352-28952022-09-0120100481Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituationSachin Patel0Keenan Johnson1Danielle Adank2Luis E. Rosas-Vidal3Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USADepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USAVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA; Interdisciplinary Program in Neuroscience, Vanderbilt University, Nashville, TN, USADepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center Nashville, TN, USA; Corresponding author. Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center Nashville, TN, USA.The prefrontal cortex is highly susceptible to the detrimental effects of stress and has been implicated in the pathogenesis of stress-related psychiatric disorders. It is not well understood, however, how stress is represented at the neuronal level in the prefrontal cortical neuronal ensembles. Even less understood is how the representation of stress changes over time with repeated exposure. Here we show that the prelimbic prefrontal neuronal ensemble representation of foot shock stress exhibits rapid spatial drift within and between sessions. Despite this rapid spatial drift of the ensemble, the representation of the stressor itself stabilizes over days. Our results suggest that stress is represented by rapidly drifting ensembles and despite this rapid drift, important features of the neuronal representation are stabilized, suggesting a neural correlate of stress habituation is present within prefrontal cortical neuron populations.http://www.sciencedirect.com/science/article/pii/S235228952200056XPrelimbicPrefrontalStressHabituationCalcium imagingGCaMP |
| spellingShingle | Sachin Patel Keenan Johnson Danielle Adank Luis E. Rosas-Vidal Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation Neurobiology of Stress Prelimbic Prefrontal Stress Habituation Calcium imaging GCaMP |
| title | Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation |
| title_full | Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation |
| title_fullStr | Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation |
| title_full_unstemmed | Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation |
| title_short | Longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation |
| title_sort | longitudinal monitoring of prefrontal cortical ensemble dynamics reveals new insights into stress habituation |
| topic | Prelimbic Prefrontal Stress Habituation Calcium imaging GCaMP |
| url | http://www.sciencedirect.com/science/article/pii/S235228952200056X |
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