Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes

Abstract Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without...

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Main Authors: Moamar Al-Jefout, Nedal Alnawaiseh, Aiman Al-Qtaitat
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05717-y
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author Moamar Al-Jefout
Nedal Alnawaiseh
Aiman Al-Qtaitat
author_facet Moamar Al-Jefout
Nedal Alnawaiseh
Aiman Al-Qtaitat
author_sort Moamar Al-Jefout
collection DOAJ
description Abstract Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without PCOS, recruited as a control group. Biometric, hormonal and clinical parameters were studied. IR was observed in 133 (83.6%) women with PCOS and in 25 (46.3%) women without PCOS (p < 0.001). IR was significantly associated with PCOS only among women with central obesity (χ2 = 35.0, p < 0.001) and not for the normal category (χ2 = 4.04, p < 0.058). The LH/FSH ratio was not significantly different among the PCOS group (n = 37, 23.3%) compared to the control group (n = 9, 16.7%) (p = 0.308). Among women with PCOS, the most common phenotype was type I (50.3%), with type III (29.6%), type II (14.5%) and type IV (5.7%). Type I had the highest values of fasting insulin (median = 12.98 mU/mL) and HOMA IR values (significant difference among the four phenotypes, p = 0.009 and 0.006, respectively) and is associated with severity of the disease. There was no difference in glucose levels.
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spelling doaj.art-970c5fc9cc9b47d0bdf31186b6e8d1092022-12-21T20:31:15ZengNature PortfolioScientific Reports2045-23222017-07-01711910.1038/s41598-017-05717-yInsulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypesMoamar Al-Jefout0Nedal Alnawaiseh1Aiman Al-Qtaitat2Department of Obstetrics and Gynaecology, Mutah Medical Faculty, Mutah UniversityDepartment of Public Health, Mutah Medical Faculty, Mutah UniversityDepartment of Anatomy and Histology, Mutah Medical Faculty, Mutah UniversityAbstract Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without PCOS, recruited as a control group. Biometric, hormonal and clinical parameters were studied. IR was observed in 133 (83.6%) women with PCOS and in 25 (46.3%) women without PCOS (p < 0.001). IR was significantly associated with PCOS only among women with central obesity (χ2 = 35.0, p < 0.001) and not for the normal category (χ2 = 4.04, p < 0.058). The LH/FSH ratio was not significantly different among the PCOS group (n = 37, 23.3%) compared to the control group (n = 9, 16.7%) (p = 0.308). Among women with PCOS, the most common phenotype was type I (50.3%), with type III (29.6%), type II (14.5%) and type IV (5.7%). Type I had the highest values of fasting insulin (median = 12.98 mU/mL) and HOMA IR values (significant difference among the four phenotypes, p = 0.009 and 0.006, respectively) and is associated with severity of the disease. There was no difference in glucose levels.https://doi.org/10.1038/s41598-017-05717-y
spellingShingle Moamar Al-Jefout
Nedal Alnawaiseh
Aiman Al-Qtaitat
Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
Scientific Reports
title Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_full Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_fullStr Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_full_unstemmed Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_short Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_sort insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
url https://doi.org/10.1038/s41598-017-05717-y
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AT nedalalnawaiseh insulinresistanceandobesityamonginfertilewomenwithdifferentpolycysticovarysyndromephenotypes
AT aimanalqtaitat insulinresistanceandobesityamonginfertilewomenwithdifferentpolycysticovarysyndromephenotypes