Kupffer Cells as a Target for Immunotherapy
Kupffer cells (KCs) are resident macrophages in the liver. Recent studies have revealed that KCs are closely related to inflammatory liver diseases, including nonalcoholic liver diseases (NAFLD). From this point of view, KC transplantation can be a candidate for immunotherapy against inflammatory di...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | J |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2571-8800/5/4/36 |
| _version_ | 1827638408103591936 |
|---|---|
| author | Takashi Sakai Wen-Ling Lin |
| author_facet | Takashi Sakai Wen-Ling Lin |
| author_sort | Takashi Sakai |
| collection | DOAJ |
| description | Kupffer cells (KCs) are resident macrophages in the liver. Recent studies have revealed that KCs are closely related to inflammatory liver diseases, including nonalcoholic liver diseases (NAFLD). From this point of view, KC transplantation can be a candidate for immunotherapy against inflammatory diseases. Similar to general macrophages, KCs show several different phenotypes according to their environment. Activated KCs are involved in either proinflammatory responses or anti-inflammatory responses. Thus, to manipulate KCs for immunotherapy, it is crucial to control the direction of KC activation. Here, we summarize the outlook and the issues hindering immunotherapy using KC transplantation. |
| first_indexed | 2024-03-09T16:16:59Z |
| format | Article |
| id | doaj.art-970dfd8a7b0c43d1adc8a2e7ad02a6f0 |
| institution | Directory Open Access Journal |
| issn | 2571-8800 |
| language | English |
| last_indexed | 2024-03-09T16:16:59Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | J |
| spelling | doaj.art-970dfd8a7b0c43d1adc8a2e7ad02a6f02023-11-24T15:41:09ZengMDPI AGJ2571-88002022-12-015453253710.3390/j5040036Kupffer Cells as a Target for ImmunotherapyTakashi Sakai0Wen-Ling Lin1Institute for Health Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima 770-8514, JapanGraduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 110, TaiwanKupffer cells (KCs) are resident macrophages in the liver. Recent studies have revealed that KCs are closely related to inflammatory liver diseases, including nonalcoholic liver diseases (NAFLD). From this point of view, KC transplantation can be a candidate for immunotherapy against inflammatory diseases. Similar to general macrophages, KCs show several different phenotypes according to their environment. Activated KCs are involved in either proinflammatory responses or anti-inflammatory responses. Thus, to manipulate KCs for immunotherapy, it is crucial to control the direction of KC activation. Here, we summarize the outlook and the issues hindering immunotherapy using KC transplantation.https://www.mdpi.com/2571-8800/5/4/36Kupffer cellsmacrophageshepatic stellate cellsimmunotherapyNAFLD |
| spellingShingle | Takashi Sakai Wen-Ling Lin Kupffer Cells as a Target for Immunotherapy J Kupffer cells macrophages hepatic stellate cells immunotherapy NAFLD |
| title | Kupffer Cells as a Target for Immunotherapy |
| title_full | Kupffer Cells as a Target for Immunotherapy |
| title_fullStr | Kupffer Cells as a Target for Immunotherapy |
| title_full_unstemmed | Kupffer Cells as a Target for Immunotherapy |
| title_short | Kupffer Cells as a Target for Immunotherapy |
| title_sort | kupffer cells as a target for immunotherapy |
| topic | Kupffer cells macrophages hepatic stellate cells immunotherapy NAFLD |
| url | https://www.mdpi.com/2571-8800/5/4/36 |
| work_keys_str_mv | AT takashisakai kupffercellsasatargetforimmunotherapy AT wenlinglin kupffercellsasatargetforimmunotherapy |