Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow
Objective Earlier studies have reported that a decrease in exercise capacity might indicate endothelial dysfunction. However, the effects of improvement of endothelial functions on exercise capacity have not been evaluated. The aim of the present study is to investigate the effects of nebivolol on f...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2009-01-01
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| Series: | Clinical Medicine Insights: Cardiology |
| Online Access: | https://doi.org/10.4137/CMC.S3725 |
| _version_ | 1818501078493167616 |
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| author | Selma Tiryakioglu Osman Tiryakioglu Hasan Ari Mehmet C. Basel Tahsin Bozat |
| author_facet | Selma Tiryakioglu Osman Tiryakioglu Hasan Ari Mehmet C. Basel Tahsin Bozat |
| author_sort | Selma Tiryakioglu |
| collection | DOAJ |
| description | Objective Earlier studies have reported that a decrease in exercise capacity might indicate endothelial dysfunction. However, the effects of improvement of endothelial functions on exercise capacity have not been evaluated. The aim of the present study is to investigate the effects of nebivolol on flow-mediated dilatation (FMD), and on the exercise capacities of the patients with slow coronary flow (SCF). Methods The study population included 25 subjects with SCF (Group 1) documented by the thrombolysis in myocardial infarction (TIMI) frame count, and 25 control group (Group 2) subjects with normal coronary angiography, for a total of 50 subjects who underwent coronary angiography due to several indications and had no coronary lesion. The TIMI frame count (TFC) values of the subjects in Group I for left anterior descending artery, right coronary, and circumflex coronary artery were 61.8 ± 30.6, 37.2 ± 17.4, and 34.6 ± 17.4, respectively. All the subjects received nebivolol 5 mg/day. Results At the end of the first month of FMD, the mean exercise duration (MED) and the Duke Scores of the patients with SCF were significantly higher than the baseline values. However, the values by the sixth month did not differ from that at the first month. Although a numerical improvement compared to the baseline values was observed for the subjects in Group 2 by the measurements at the end of the first and the sixth month, this difference was not statistically significant. Conclusions Nebivolol treatment increases FMD in the subjects with SCF. The difference in the exercise parameters of these subjects is particularly dramatic, and such an outcome may indirectly indicate long-term improvement in endothelial function. |
| first_indexed | 2024-12-10T20:51:18Z |
| format | Article |
| id | doaj.art-970ffb39104743d1ae482f3a19bd6fb1 |
| institution | Directory Open Access Journal |
| issn | 1179-5468 |
| language | English |
| last_indexed | 2024-12-10T20:51:18Z |
| publishDate | 2009-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Cardiology |
| spelling | doaj.art-970ffb39104743d1ae482f3a19bd6fb12022-12-22T01:34:05ZengSAGE PublishingClinical Medicine Insights: Cardiology1179-54682009-01-01310.4137/CMC.S3725Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary FlowSelma Tiryakioglu0Osman Tiryakioglu1Hasan Ari2Mehmet C. Basel3Tahsin Bozat4Bursa Acibadem Hospital, Department of Cardiology, Bursa, Turkey.Bursa Yuksek ihtisas Training and Research Hospital, Department of Cardiovascular Surgery, Bursa, Turkey.Bursa Yuksek ihtisas Training and Research Hospital, Department of Cardiovascular Surgery, Bursa, Turkey.Bursa Yuksek ihtisas Training and Research Hospital, Department of Cardiovascular Surgery, Bursa, Turkey.Bursa Yuksek ihtisas Training and Research Hospital, Department of Cardiovascular Surgery, Bursa, Turkey.Objective Earlier studies have reported that a decrease in exercise capacity might indicate endothelial dysfunction. However, the effects of improvement of endothelial functions on exercise capacity have not been evaluated. The aim of the present study is to investigate the effects of nebivolol on flow-mediated dilatation (FMD), and on the exercise capacities of the patients with slow coronary flow (SCF). Methods The study population included 25 subjects with SCF (Group 1) documented by the thrombolysis in myocardial infarction (TIMI) frame count, and 25 control group (Group 2) subjects with normal coronary angiography, for a total of 50 subjects who underwent coronary angiography due to several indications and had no coronary lesion. The TIMI frame count (TFC) values of the subjects in Group I for left anterior descending artery, right coronary, and circumflex coronary artery were 61.8 ± 30.6, 37.2 ± 17.4, and 34.6 ± 17.4, respectively. All the subjects received nebivolol 5 mg/day. Results At the end of the first month of FMD, the mean exercise duration (MED) and the Duke Scores of the patients with SCF were significantly higher than the baseline values. However, the values by the sixth month did not differ from that at the first month. Although a numerical improvement compared to the baseline values was observed for the subjects in Group 2 by the measurements at the end of the first and the sixth month, this difference was not statistically significant. Conclusions Nebivolol treatment increases FMD in the subjects with SCF. The difference in the exercise parameters of these subjects is particularly dramatic, and such an outcome may indirectly indicate long-term improvement in endothelial function.https://doi.org/10.4137/CMC.S3725 |
| spellingShingle | Selma Tiryakioglu Osman Tiryakioglu Hasan Ari Mehmet C. Basel Tahsin Bozat Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow Clinical Medicine Insights: Cardiology |
| title | Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow |
| title_full | Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow |
| title_fullStr | Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow |
| title_full_unstemmed | Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow |
| title_short | Effects of Nebivolol on Endothelial Function and Exercise Parameters in Patients with Slow Coronary Flow |
| title_sort | effects of nebivolol on endothelial function and exercise parameters in patients with slow coronary flow |
| url | https://doi.org/10.4137/CMC.S3725 |
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