No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder
Deep brain stimulation (DBS) of the ventral internal capsule is effective in treating therapy refractory obsessive-compulsive disorder (OCD). Given the close proximity of the stimulation site to the stria terminalis (BNST), we hypothesized that the striking decrease in anxiety symptoms following DBS...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-09-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00305/full |
| _version_ | 1819081291662884864 |
|---|---|
| author | Johanna M.P. Baas Johanna M.P. Baas Floris eKlumpers Mariska H Mantione Martijn eFigee Nienke C Vulink P. Richard Schuurman Ali eMazaheri Damiaan eDenys Damiaan eDenys |
| author_facet | Johanna M.P. Baas Johanna M.P. Baas Floris eKlumpers Mariska H Mantione Martijn eFigee Nienke C Vulink P. Richard Schuurman Ali eMazaheri Damiaan eDenys Damiaan eDenys |
| author_sort | Johanna M.P. Baas |
| collection | DOAJ |
| description | Deep brain stimulation (DBS) of the ventral internal capsule is effective in treating therapy refractory obsessive-compulsive disorder (OCD). Given the close proximity of the stimulation site to the stria terminalis (BNST), we hypothesized that the striking decrease in anxiety symptoms following DBS could be the result of the modulation of contextual anxiety. However, the effect of DBS in this region on contextual anxiety is as of yet unknown. Thus, the current study investigated the effect of DBS on contextual anxiety in an experimental threat of shock paradigm. Eight patients with DBS treatment for severe OCD were tested in a double-blind crossover design with randomly assigned two-week periods of active and sham stimulation. DBS resulted in significant decrease of obsessive-compulsive symptoms, anxiety and depression. However, even though the threat manipulation resulted in a clear context potentiated startle effect, none of the parameters derived from the startle recordings was modulated by the DBS. This suggests that DBS in the ventral internal capsule is effective in treating anxiety symptoms of obsessive-compulsive disorder without modulating the startle circuitry. We hypothesize that the anxiety symptoms present in OCD are likely distinct from the pathological brain circuits in defensive states of other anxiety disorders. |
| first_indexed | 2024-12-21T19:58:27Z |
| format | Article |
| id | doaj.art-971434d49d1846f3bc09736f70731b3e |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-21T19:58:27Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-971434d49d1846f3bc09736f70731b3e2022-12-21T18:52:02ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-09-01810.3389/fnbeh.2014.00305107221No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorderJohanna M.P. Baas0Johanna M.P. Baas1Floris eKlumpers2Mariska H Mantione3Martijn eFigee4Nienke C Vulink5P. Richard Schuurman6Ali eMazaheri7Damiaan eDenys8Damiaan eDenys9Utrecht UniversityHelmholtz InstituteDonders Institute for Brain, Cognition and BehaviorAcademic Medical CenterAcademic Medical CenterAcademic Medical CenterAcademic Medical CenterAcademic Medical CenterAcademic Medical CenterNetherlands Institute for NeuroscienceDeep brain stimulation (DBS) of the ventral internal capsule is effective in treating therapy refractory obsessive-compulsive disorder (OCD). Given the close proximity of the stimulation site to the stria terminalis (BNST), we hypothesized that the striking decrease in anxiety symptoms following DBS could be the result of the modulation of contextual anxiety. However, the effect of DBS in this region on contextual anxiety is as of yet unknown. Thus, the current study investigated the effect of DBS on contextual anxiety in an experimental threat of shock paradigm. Eight patients with DBS treatment for severe OCD were tested in a double-blind crossover design with randomly assigned two-week periods of active and sham stimulation. DBS resulted in significant decrease of obsessive-compulsive symptoms, anxiety and depression. However, even though the threat manipulation resulted in a clear context potentiated startle effect, none of the parameters derived from the startle recordings was modulated by the DBS. This suggests that DBS in the ventral internal capsule is effective in treating anxiety symptoms of obsessive-compulsive disorder without modulating the startle circuitry. We hypothesize that the anxiety symptoms present in OCD are likely distinct from the pathological brain circuits in defensive states of other anxiety disorders.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00305/fullcontextdeep brain stimulation (DBS)fear-potentiated startleObsessive-compulsive disorder (OCD)bed nucleus of the stria terminalis (BNST) |
| spellingShingle | Johanna M.P. Baas Johanna M.P. Baas Floris eKlumpers Mariska H Mantione Martijn eFigee Nienke C Vulink P. Richard Schuurman Ali eMazaheri Damiaan eDenys Damiaan eDenys No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder Frontiers in Behavioral Neuroscience context deep brain stimulation (DBS) fear-potentiated startle Obsessive-compulsive disorder (OCD) bed nucleus of the stria terminalis (BNST) |
| title | No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder |
| title_full | No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder |
| title_fullStr | No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder |
| title_full_unstemmed | No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder |
| title_short | No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder |
| title_sort | no impact of deep brain stimulation on fear potentiated startle in obsessive compulsive disorder |
| topic | context deep brain stimulation (DBS) fear-potentiated startle Obsessive-compulsive disorder (OCD) bed nucleus of the stria terminalis (BNST) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00305/full |
| work_keys_str_mv | AT johannampbaas noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT johannampbaas noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT floriseklumpers noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT mariskahmantione noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT martijnefigee noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT nienkecvulink noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT prichardschuurman noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT aliemazaheri noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT damiaanedenys noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder AT damiaanedenys noimpactofdeepbrainstimulationonfearpotentiatedstartleinobsessivecompulsivedisorder |