Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction
Abstract Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to pl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-02322-w |
| _version_ | 1819024828204580864 |
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| author | Wenkai Liao Li Xu Yuxia Pan Jie Wei Peijia Wang Xinchun Yang Mulei Chen Yuanfeng Gao |
| author_facet | Wenkai Liao Li Xu Yuxia Pan Jie Wei Peijia Wang Xinchun Yang Mulei Chen Yuanfeng Gao |
| author_sort | Wenkai Liao |
| collection | DOAJ |
| description | Abstract Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p < 0.001) than those without AA. AA patients also tended to be elderly (65.25 ± 9.98 years vs 57.47 ± 10.78 years, p < 0.001), had higher Hs-CRP (39.74 ± 43.50 mg/L vs 12.22 ± 19.25 mg/L, p < 0.001) and worse heart function. TSP-1 (OR 1.033; 95% CI 1.003–1.065, p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion TSP-1 is a potential novel indicator of atrial arrhythmias during AMI. Graphical abstract |
| first_indexed | 2024-12-21T05:00:59Z |
| format | Article |
| id | doaj.art-9714c38885a046f6b9cf5c1a816f4ccf |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-21T05:00:59Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-9714c38885a046f6b9cf5c1a816f4ccf2022-12-21T19:15:15ZengBMCBMC Cardiovascular Disorders1471-22612021-10-012111710.1186/s12872-021-02322-wAssociation of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarctionWenkai Liao0Li Xu1Yuxia Pan2Jie Wei3Peijia Wang4Xinchun Yang5Mulei Chen6Yuanfeng Gao7Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical UniversityAbstract Objectives Atrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias. Methods A total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital. Results Twenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p < 0.001) than those without AA. AA patients also tended to be elderly (65.25 ± 9.98 years vs 57.47 ± 10.78 years, p < 0.001), had higher Hs-CRP (39.74 ± 43.50 mg/L vs 12.22 ± 19.25 mg/L, p < 0.001) and worse heart function. TSP-1 (OR 1.033; 95% CI 1.003–1.065, p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients. Conclusion TSP-1 is a potential novel indicator of atrial arrhythmias during AMI. Graphical abstracthttps://doi.org/10.1186/s12872-021-02322-wAtrial arrhythmiasAtrial fibrillationAtrial remodelingAcute myocardial infarctionThrombospondin-1 |
| spellingShingle | Wenkai Liao Li Xu Yuxia Pan Jie Wei Peijia Wang Xinchun Yang Mulei Chen Yuanfeng Gao Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction BMC Cardiovascular Disorders Atrial arrhythmias Atrial fibrillation Atrial remodeling Acute myocardial infarction Thrombospondin-1 |
| title | Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction |
| title_full | Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction |
| title_fullStr | Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction |
| title_full_unstemmed | Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction |
| title_short | Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction |
| title_sort | association of atrial arrhythmias with thrombospondin 1 in patients with acute myocardial infarction |
| topic | Atrial arrhythmias Atrial fibrillation Atrial remodeling Acute myocardial infarction Thrombospondin-1 |
| url | https://doi.org/10.1186/s12872-021-02322-w |
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