Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer

Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer

Pancreatic adenocarcinoma, one of the worst malignancies of the exocrine pancreas, is a solid tumor with increasing incidence and mortality in industrialized countries. This condition is usually driven by oncogenic KRAS point mutations and evolves into a highly aggressive metastatic carcinoma due to...

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Bibliographic Details
Main Authors: Marco Schiavone, Elena Rampazzo, Alessandro Casari, Giusy Battilana, Luca Persano, Enrico Moro, Shu Liu, Steve D. Leach, Natascia Tiso, Francesco Argenton
Format: Article
Language:English
Published: The Company of Biologists 2014-07-01
Series:Disease Models & Mechanisms
Subjects:
Zebrafish
Pancreatic adenocarcinoma
Medulloblastoma
KRAS
Reporters
TGFβ
Notch
Shh
Online Access:http://dmm.biologists.org/content/7/7/883

Internet

http://dmm.biologists.org/content/7/7/883

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