Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-Based Sialylation in Human Breast Cells: Implications for Cancer Progression

Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-Based Sialylation in Human Breast Cells: Implications for Cancer Progression

Sialylation, a post-translational modification that impacts the structure, activity, and longevity of glycoproteins has been thought to be controlled primarily by the expression of sialyltransferases (STs). In this report we explore the complementary impact of metabolic flux on sialylation using a g...

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Bibliographic Details
Main Authors: Christopher T. Saeui, Kyung-cho Cho, Vrinda Dharmarha, Alison V. Nairn, Melina Galizzi, Sagar R. Shah, Prateek Gowda, Marian Park, Melissa Austin, Amelia Clarke, Edward Cai, Matthew J. Buettner, Ryan Ariss, Kelley W. Moremen, Hui Zhang, Kevin J. Yarema
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Chemistry
Subjects:
metabolic glycoengineering
ManNAc analogs
breast cancer
sialylation
sialic acid
metabolic flux
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00013/full

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