Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia
The skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess the pathogenesis and progression of androgenetic alopecia (AGA), we analyzed the composition of sebum and the bacterial and fungal microbiomes of the scalps of 118 Japanese male individuals wit...
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MDPI AG
2021-10-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/10/2132 |
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| author | Kazuhiro Suzuki Mizuna Inoue Otomi Cho Rumiko Mizutani Yuri Shimizu Tohru Nagahama Takashi Sugita |
| author_facet | Kazuhiro Suzuki Mizuna Inoue Otomi Cho Rumiko Mizutani Yuri Shimizu Tohru Nagahama Takashi Sugita |
| author_sort | Kazuhiro Suzuki |
| collection | DOAJ |
| description | The skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess the pathogenesis and progression of androgenetic alopecia (AGA), we analyzed the composition of sebum and the bacterial and fungal microbiomes of the scalps of 118 Japanese male individuals with and without AGA, then discussed their roles in the pathogenesis of AGA. Sebum triglyceride and palmitic acid contents were higher in the AGA group than in the non-AGA group. <i>Malassezia restricta</i>, a lipophilic fungus that consumes palmitic acid, was abundant on the scalps of patients with AGA. <i>Cutibacterium</i>, <i>Corynebacterium</i>, and <i>Staphylococcus</i> were the most common genera in both groups, and patients with AGA exhibited scalp dysbiosis (increased abundance of <i>Cutibacterium</i> and decreased abundance of <i>Corynebacterium</i>). Our findings suggest that both sebum and the bacterial and fungal microbiomes of the scalp may be involved in the development of AGA. |
| first_indexed | 2024-03-10T06:22:14Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T06:22:14Z |
| publishDate | 2021-10-01 |
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| series | Microorganisms |
| spelling | doaj.art-971b024af7fa45fa886753865dfa69782023-11-22T19:14:50ZengMDPI AGMicroorganisms2076-26072021-10-01910213210.3390/microorganisms9102132Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic AlopeciaKazuhiro Suzuki0Mizuna Inoue1Otomi Cho2Rumiko Mizutani3Yuri Shimizu4Tohru Nagahama5Takashi Sugita6Department of Microbiology, Meiji Pharmaceutical University, Kiyose 204-8588, JapanResearch & Development Headquarters Self-Medication, Taisho Pharmaceutical Co., Ltd., Saitama 331-9530, JapanDepartment of Microbiology, Meiji Pharmaceutical University, Kiyose 204-8588, JapanResearch & Development Headquarters Self-Medication, Taisho Pharmaceutical Co., Ltd., Saitama 331-9530, JapanResearch & Development Headquarters Self-Medication, Taisho Pharmaceutical Co., Ltd., Saitama 331-9530, JapanResearch & Development Headquarters Self-Medication, Taisho Pharmaceutical Co., Ltd., Saitama 331-9530, JapanDepartment of Microbiology, Meiji Pharmaceutical University, Kiyose 204-8588, JapanThe skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess the pathogenesis and progression of androgenetic alopecia (AGA), we analyzed the composition of sebum and the bacterial and fungal microbiomes of the scalps of 118 Japanese male individuals with and without AGA, then discussed their roles in the pathogenesis of AGA. Sebum triglyceride and palmitic acid contents were higher in the AGA group than in the non-AGA group. <i>Malassezia restricta</i>, a lipophilic fungus that consumes palmitic acid, was abundant on the scalps of patients with AGA. <i>Cutibacterium</i>, <i>Corynebacterium</i>, and <i>Staphylococcus</i> were the most common genera in both groups, and patients with AGA exhibited scalp dysbiosis (increased abundance of <i>Cutibacterium</i> and decreased abundance of <i>Corynebacterium</i>). Our findings suggest that both sebum and the bacterial and fungal microbiomes of the scalp may be involved in the development of AGA.https://www.mdpi.com/2076-2607/9/10/2132androgenetic alopeciascalpmicrobiomesebum composition<i>Malassezia</i> |
| spellingShingle | Kazuhiro Suzuki Mizuna Inoue Otomi Cho Rumiko Mizutani Yuri Shimizu Tohru Nagahama Takashi Sugita Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia Microorganisms androgenetic alopecia scalp microbiome sebum composition <i>Malassezia</i> |
| title | Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia |
| title_full | Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia |
| title_fullStr | Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia |
| title_full_unstemmed | Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia |
| title_short | Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia |
| title_sort | scalp microbiome and sebum composition in japanese male individuals with and without androgenetic alopecia |
| topic | androgenetic alopecia scalp microbiome sebum composition <i>Malassezia</i> |
| url | https://www.mdpi.com/2076-2607/9/10/2132 |
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