The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases
An mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection. Most cases of mpox in sold organ transplant (SOT) recipients reported in the literature were...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224000869 |
| _version_ | 1797198797090062336 |
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| author | Reem M. Alameer Amani Yamani Abdulrahman Al-Saud Sultan Alsobayeg Bayan Alamro Alaa Alali Ehab Hammad Ali M. Shendi Reem S. Almaghrabi |
| author_facet | Reem M. Alameer Amani Yamani Abdulrahman Al-Saud Sultan Alsobayeg Bayan Alamro Alaa Alali Ehab Hammad Ali M. Shendi Reem S. Almaghrabi |
| author_sort | Reem M. Alameer |
| collection | DOAJ |
| description | An mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection. Most cases of mpox in sold organ transplant (SOT) recipients reported in the literature were treated with tecovirimat. Here we report two cases of severe disseminated mpox infection in renal transplant recipients that were successfully treated with brincidofovir. Both patients were discharged from the hospital with no immediate significant side effects from brincidofovir reported until the submission of this report. |
| first_indexed | 2024-04-24T07:05:34Z |
| format | Article |
| id | doaj.art-971beada9fa6428e9357dd4d4e15cda6 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-24T07:05:34Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-971beada9fa6428e9357dd4d4e15cda62024-04-22T04:11:31ZengElsevierInternational Journal of Infectious Diseases1201-97122024-06-01143107015The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 casesReem M. Alameer0Amani Yamani1Abdulrahman Al-Saud2Sultan Alsobayeg3Bayan Alamro4Alaa Alali5Ehab Hammad6Ali M. Shendi7Reem S. Almaghrabi8Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Corresponding author: Reem M. Alameer, Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaSection of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaDepartment of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaDepartment of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaDepartment of Infectious Diseases, King Saud Medical City, Riyadh, Saudi ArabiaKidney and Pancreas Health Center, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaKidney and Pancreas Health Center, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaSection of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaAn mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection. Most cases of mpox in sold organ transplant (SOT) recipients reported in the literature were treated with tecovirimat. Here we report two cases of severe disseminated mpox infection in renal transplant recipients that were successfully treated with brincidofovir. Both patients were discharged from the hospital with no immediate significant side effects from brincidofovir reported until the submission of this report.http://www.sciencedirect.com/science/article/pii/S1201971224000869MpoxMonkeypox virusBrincidofovirSolid organ transplantRenal transplantKidney transplant |
| spellingShingle | Reem M. Alameer Amani Yamani Abdulrahman Al-Saud Sultan Alsobayeg Bayan Alamro Alaa Alali Ehab Hammad Ali M. Shendi Reem S. Almaghrabi The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases International Journal of Infectious Diseases Mpox Monkeypox virus Brincidofovir Solid organ transplant Renal transplant Kidney transplant |
| title | The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases |
| title_full | The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases |
| title_fullStr | The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases |
| title_full_unstemmed | The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases |
| title_short | The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases |
| title_sort | successful treatment of mpox with brincidofovir in renal transplant recipients a report of 2 cases |
| topic | Mpox Monkeypox virus Brincidofovir Solid organ transplant Renal transplant Kidney transplant |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224000869 |
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