Review on the roles of specific cell-derived exosomes in Alzheimer's disease
Alzheimer's disease (AD) is the sixth leading cause of death worldwide and cannot be effectively cured or prevented; thus, early diagnosis, and intervention are important. The importance of exosomes, membrane-bound extracellular vesicles produced in the endosome of eukaryotic cells, in the deve...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.936760/full |
| _version_ | 1818160559035514880 |
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| author | Yutong Zou Danni Mu Xiaoli Ma Xiaoli Ma Danchen Wang Jian Zhong Jing Gao Songlin Yu Ling Qiu Ling Qiu |
| author_facet | Yutong Zou Danni Mu Xiaoli Ma Xiaoli Ma Danchen Wang Jian Zhong Jing Gao Songlin Yu Ling Qiu Ling Qiu |
| author_sort | Yutong Zou |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is the sixth leading cause of death worldwide and cannot be effectively cured or prevented; thus, early diagnosis, and intervention are important. The importance of exosomes, membrane-bound extracellular vesicles produced in the endosome of eukaryotic cells, in the development, diagnosis, and treatment of AD has been recognized; however, their specific functions remain controversial and even unclear. With the development of exosome extraction, isolation, and characterization, many studies have focused on exosomes derived from different cells and body fluids. In this study, we summarized the roles of exosomes derived from different body fluids and cells, such as neuron, glial, stem, and endothelial cells, in the development, diagnosis, monitoring, and treatment of AD. We also emphasize the necessity to focus on exosomes from biological fluids and specific cells that are less invasive to target. Moreover, aside from the concentrations of classic and novel biomarkers in exosomes, the size and number of exosomes may also influence early and differential diagnosis of AD. |
| first_indexed | 2024-12-11T16:03:48Z |
| format | Article |
| id | doaj.art-971c316f44544f1989040dbd9e503833 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T16:03:48Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-971c316f44544f1989040dbd9e5038332022-12-22T00:59:14ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-07-011610.3389/fnins.2022.936760936760Review on the roles of specific cell-derived exosomes in Alzheimer's diseaseYutong Zou0Danni Mu1Xiaoli Ma2Xiaoli Ma3Danchen Wang4Jian Zhong5Jing Gao6Songlin Yu7Ling Qiu8Ling Qiu9Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaMedical Science Research Center (MRC), Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, ChinaState Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, ChinaAlzheimer's disease (AD) is the sixth leading cause of death worldwide and cannot be effectively cured or prevented; thus, early diagnosis, and intervention are important. The importance of exosomes, membrane-bound extracellular vesicles produced in the endosome of eukaryotic cells, in the development, diagnosis, and treatment of AD has been recognized; however, their specific functions remain controversial and even unclear. With the development of exosome extraction, isolation, and characterization, many studies have focused on exosomes derived from different cells and body fluids. In this study, we summarized the roles of exosomes derived from different body fluids and cells, such as neuron, glial, stem, and endothelial cells, in the development, diagnosis, monitoring, and treatment of AD. We also emphasize the necessity to focus on exosomes from biological fluids and specific cells that are less invasive to target. Moreover, aside from the concentrations of classic and novel biomarkers in exosomes, the size and number of exosomes may also influence early and differential diagnosis of AD.https://www.frontiersin.org/articles/10.3389/fnins.2022.936760/fullAlzheimer's diseasemild cognitive impairmentexosomebiomarkersneuronglial cells |
| spellingShingle | Yutong Zou Danni Mu Xiaoli Ma Xiaoli Ma Danchen Wang Jian Zhong Jing Gao Songlin Yu Ling Qiu Ling Qiu Review on the roles of specific cell-derived exosomes in Alzheimer's disease Frontiers in Neuroscience Alzheimer's disease mild cognitive impairment exosome biomarkers neuron glial cells |
| title | Review on the roles of specific cell-derived exosomes in Alzheimer's disease |
| title_full | Review on the roles of specific cell-derived exosomes in Alzheimer's disease |
| title_fullStr | Review on the roles of specific cell-derived exosomes in Alzheimer's disease |
| title_full_unstemmed | Review on the roles of specific cell-derived exosomes in Alzheimer's disease |
| title_short | Review on the roles of specific cell-derived exosomes in Alzheimer's disease |
| title_sort | review on the roles of specific cell derived exosomes in alzheimer s disease |
| topic | Alzheimer's disease mild cognitive impairment exosome biomarkers neuron glial cells |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.936760/full |
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