Neural repair in the adult brain [version 1; referees: 3 approved]
Acute or chronic injury to the adult brain often results in substantial loss of neural tissue and subsequent permanent functional impairment. Over the last two decades, a number of approaches have been developed to harness the regenerative potential of neural stem cells and the existing fate plastic...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-02-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/5-169/v1 |
| _version_ | 1818111878191120384 |
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| author | Sebastian Jessberger |
| author_facet | Sebastian Jessberger |
| author_sort | Sebastian Jessberger |
| collection | DOAJ |
| description | Acute or chronic injury to the adult brain often results in substantial loss of neural tissue and subsequent permanent functional impairment. Over the last two decades, a number of approaches have been developed to harness the regenerative potential of neural stem cells and the existing fate plasticity of neural cells in the nervous system to prevent tissue loss or to enhance structural and functional regeneration upon injury. Here, we review recent advances of stem cell-associated neural repair in the adult brain, discuss current challenges and limitations, and suggest potential directions to foster the translation of experimental stem cell therapies into the clinic. |
| first_indexed | 2024-12-11T03:10:02Z |
| format | Article |
| id | doaj.art-971d2d4f734e4786a967d3f45a63979f |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T03:10:02Z |
| publishDate | 2016-02-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-971d2d4f734e4786a967d3f45a63979f2022-12-22T01:22:54ZengF1000 Research LtdF1000Research2046-14022016-02-01510.12688/f1000research.7459.18037Neural repair in the adult brain [version 1; referees: 3 approved]Sebastian Jessberger0Laboratory of Neural Plasticity, Brain Research Institute, Faculty of Medicine and Science, University of Zurich, Zurich, SwitzerlandAcute or chronic injury to the adult brain often results in substantial loss of neural tissue and subsequent permanent functional impairment. Over the last two decades, a number of approaches have been developed to harness the regenerative potential of neural stem cells and the existing fate plasticity of neural cells in the nervous system to prevent tissue loss or to enhance structural and functional regeneration upon injury. Here, we review recent advances of stem cell-associated neural repair in the adult brain, discuss current challenges and limitations, and suggest potential directions to foster the translation of experimental stem cell therapies into the clinic.http://f1000research.com/articles/5-169/v1AgingBehavioral NeuroscienceCognitive NeuroscienceDevelopmental Molecular MechanismsNeurobiology of Disease & RegenerationNeurodevelopmentStem Cells & Regeneration |
| spellingShingle | Sebastian Jessberger Neural repair in the adult brain [version 1; referees: 3 approved] F1000Research Aging Behavioral Neuroscience Cognitive Neuroscience Developmental Molecular Mechanisms Neurobiology of Disease & Regeneration Neurodevelopment Stem Cells & Regeneration |
| title | Neural repair in the adult brain [version 1; referees: 3 approved] |
| title_full | Neural repair in the adult brain [version 1; referees: 3 approved] |
| title_fullStr | Neural repair in the adult brain [version 1; referees: 3 approved] |
| title_full_unstemmed | Neural repair in the adult brain [version 1; referees: 3 approved] |
| title_short | Neural repair in the adult brain [version 1; referees: 3 approved] |
| title_sort | neural repair in the adult brain version 1 referees 3 approved |
| topic | Aging Behavioral Neuroscience Cognitive Neuroscience Developmental Molecular Mechanisms Neurobiology of Disease & Regeneration Neurodevelopment Stem Cells & Regeneration |
| url | http://f1000research.com/articles/5-169/v1 |
| work_keys_str_mv | AT sebastianjessberger neuralrepairintheadultbrainversion1referees3approved |