The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM)
The many problems in preparing fission product 99Mo led into this work to develop 99Mo/99mTc generator using neutron-irradiated natural MoO3 targets and, more specifically, to develop a zirconium-based material (ZBM) for chromatography columns that have an adsorption capacity of more than 100 mg Mo/...
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| Format: | Article |
| Language: | English |
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Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN)
2015-08-01
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| Series: | Atom Indonesia |
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| Online Access: | http://aij.batan.go.id/index.php/aij/article/view/384 |
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| author | I. Saptiama Marlina E. Sarmini Herlina Sriyono Abidin H. Setiawan Kadarisman H. Lubis A. Mutalib |
| author_facet | I. Saptiama Marlina E. Sarmini Herlina Sriyono Abidin H. Setiawan Kadarisman H. Lubis A. Mutalib |
| author_sort | I. Saptiama |
| collection | DOAJ |
| description | The many problems in preparing fission product 99Mo led into this work to develop 99Mo/99mTc generator using neutron-irradiated natural MoO3 targets and, more specifically, to develop a zirconium-based material (ZBM) for chromatography columns that have an adsorption capacity of more than 100 mg Mo/g ZBM. This paper reports our recent experiments in the use of sodium hypochlorite solution of various concentrations to improve the yield of 99mTc in performance of (n,γ)99Mo/99mTc generators based on the ZBM. The synthesized ZBM was coated with tetraethyl orthosilicate for improving the hardness of the material. The adsorption of [99Mo]molybdate into ZBM was carried out by reacting ZBM into [99Mo]molybdate solution at 90°C to form ZBM-[99Mo] molybdate. ZBM-[99Mo]molybdate was then packed into generator column, then eluted with 10 × 1 mL of saline followed by 1 × 5 mL of NaOCl solution. The NaOCl solution concentrations used were 0.5%; 1%; 3%; and 5% for each column, respectively. This study resulted in a ZBM which has a 99Mo adsorption capacity of 167.5 ± 3.4 mgMo/g ZBM, as well as in a yield eluate of 99mTc of up to 70%, and the find that the optimum NaOCl concentration was 3%. The use of sodium hypochlorite solution affected 99Mo breakthrough. The higher sodium hypochlorite concentration used, the more 99Mo breaktrough exist on 99mTc eluate. |
| first_indexed | 2024-12-13T06:05:54Z |
| format | Article |
| id | doaj.art-971e586bb0b84a14867f9d18e6ee3640 |
| institution | Directory Open Access Journal |
| issn | 0126-1568 |
| language | English |
| last_indexed | 2024-12-13T06:05:54Z |
| publishDate | 2015-08-01 |
| publisher | Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN) |
| record_format | Article |
| series | Atom Indonesia |
| spelling | doaj.art-971e586bb0b84a14867f9d18e6ee36402022-12-21T23:57:14ZengCenter for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN)Atom Indonesia0126-15682015-08-01412103109The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM)I. Saptiama 0Marlina 1E. Sarmini 2Herlina 3Sriyono 4Abidin 5H. Setiawan 6Kadarisman 7H. Lubis 8A. Mutalib 9Center for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaCenter for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy Agency Puspiptek Area Serpong, Tangerang 15314, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Science, Padjadjaran University Jl. Raya Bandung-Sumedang Km.21 Jatinangor, Sumedang 45363, IndonesiaThe many problems in preparing fission product 99Mo led into this work to develop 99Mo/99mTc generator using neutron-irradiated natural MoO3 targets and, more specifically, to develop a zirconium-based material (ZBM) for chromatography columns that have an adsorption capacity of more than 100 mg Mo/g ZBM. This paper reports our recent experiments in the use of sodium hypochlorite solution of various concentrations to improve the yield of 99mTc in performance of (n,γ)99Mo/99mTc generators based on the ZBM. The synthesized ZBM was coated with tetraethyl orthosilicate for improving the hardness of the material. The adsorption of [99Mo]molybdate into ZBM was carried out by reacting ZBM into [99Mo]molybdate solution at 90°C to form ZBM-[99Mo] molybdate. ZBM-[99Mo]molybdate was then packed into generator column, then eluted with 10 × 1 mL of saline followed by 1 × 5 mL of NaOCl solution. The NaOCl solution concentrations used were 0.5%; 1%; 3%; and 5% for each column, respectively. This study resulted in a ZBM which has a 99Mo adsorption capacity of 167.5 ± 3.4 mgMo/g ZBM, as well as in a yield eluate of 99mTc of up to 70%, and the find that the optimum NaOCl concentration was 3%. The use of sodium hypochlorite solution affected 99Mo breakthrough. The higher sodium hypochlorite concentration used, the more 99Mo breaktrough exist on 99mTc eluate.http://aij.batan.go.id/index.php/aij/article/view/38499Mo/99mTc generatorZirconium materialAdsorption capacitySodium hypochloriteYield of 99mTc |
| spellingShingle | I. Saptiama Marlina E. Sarmini Herlina Sriyono Abidin H. Setiawan Kadarisman H. Lubis A. Mutalib The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) Atom Indonesia 99Mo/99mTc generator Zirconium material Adsorption capacity Sodium hypochlorite Yield of 99mTc |
| title | The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) |
| title_full | The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) |
| title_fullStr | The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) |
| title_full_unstemmed | The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) |
| title_short | The Use of Sodium Hypochlorite Solution for (n,γ)99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM) |
| title_sort | use of sodium hypochlorite solution for n γ 99mo 99mtc generator based on zirconium based material zbm |
| topic | 99Mo/99mTc generator Zirconium material Adsorption capacity Sodium hypochlorite Yield of 99mTc |
| url | http://aij.batan.go.id/index.php/aij/article/view/384 |
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