IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells

IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells

Natural killer (NK) cells are lymphocytes with potent antitumor functions and, consequently, several NK cell-based strategies have been developed for cancer immunotherapy. A remarkable therapeutic approach is the adoptive transfer of NK cells stimulated with IL-12, IL-15 and IL-18. This cytokine sti...

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Bibliographic Details
Main Authors: Iñigo Terrén, Víctor Sandá, Ainhoa Amarilla-Irusta, Ainara Lopez-Pardo, Arrate Sevilla, Gabirel Astarloa-Pando, Laura Amo, Olatz Zenarruzabeitia, Luca Scorrano, Francisco Borrego
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
NK cells
mitochondria
cytokine-preactivated NK cells
memory-like
cancer immunotherapy
IL-12
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211839/full

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