Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases
The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal c...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10987-3 |
| _version_ | 1818342183083704320 |
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| author | Jing Sun Cheng Wang Yi Zhang Lingyan Xu Weijia Fang Yuping Zhu Yi Zheng Xiaofeng Chen Xiju Xie Xinhua Hu Weidong Hu Jingyu Zheng Ping Li Jian Yu Zhu Mei Xiaomin Cai Biao Wang Zhibin Hu Yongqian Shu Hongbing Shen Yanhong Gu |
| author_facet | Jing Sun Cheng Wang Yi Zhang Lingyan Xu Weijia Fang Yuping Zhu Yi Zheng Xiaofeng Chen Xiju Xie Xinhua Hu Weidong Hu Jingyu Zheng Ping Li Jian Yu Zhu Mei Xiaomin Cai Biao Wang Zhibin Hu Yongqian Shu Hongbing Shen Yanhong Gu |
| author_sort | Jing Sun |
| collection | DOAJ |
| description | The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal cancer. |
| first_indexed | 2024-12-13T16:10:38Z |
| format | Article |
| id | doaj.art-971f843531b644688afff75b88f27399 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:10:38Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-971f843531b644688afff75b88f273992022-12-21T23:38:57ZengNature PortfolioNature Communications2041-17232019-07-011011910.1038/s41467-019-10987-3Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastasesJing Sun0Cheng Wang1Yi Zhang2Lingyan Xu3Weijia Fang4Yuping Zhu5Yi Zheng6Xiaofeng Chen7Xiju Xie8Xinhua Hu9Weidong Hu10Jingyu Zheng11Ping Li12Jian Yu13Zhu Mei14Xiaomin Cai15Biao Wang16Zhibin Hu17Yongqian Shu18Hongbing Shen19Yanhong Gu20Department of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical UniversityDepartment of General Surgery, The First Affiliated Hospital of Nanjing University of Chinese MedicineDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityCancer Biotherapy Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Colorectal Surgery, The Zhejiang Cancer HospitalCancer Biotherapy Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of General Surgery, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of neurosurgery, The Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Neurology, The Second Affiliated Hospital of Soochow UniversityDepartment of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical SchoolDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Pathology and Radiation Oncology, University of Pittsburgh School of MedicineDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityThe development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal cancer.https://doi.org/10.1038/s41467-019-10987-3 |
| spellingShingle | Jing Sun Cheng Wang Yi Zhang Lingyan Xu Weijia Fang Yuping Zhu Yi Zheng Xiaofeng Chen Xiju Xie Xinhua Hu Weidong Hu Jingyu Zheng Ping Li Jian Yu Zhu Mei Xiaomin Cai Biao Wang Zhibin Hu Yongqian Shu Hongbing Shen Yanhong Gu Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases Nature Communications |
| title | Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_full | Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_fullStr | Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_full_unstemmed | Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_short | Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_sort | genomic signatures reveal dna damage response deficiency in colorectal cancer brain metastases |
| url | https://doi.org/10.1038/s41467-019-10987-3 |
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