Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases

Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases

The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal c...

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Bibliographic Details
Main Authors: Jing Sun, Cheng Wang, Yi Zhang, Lingyan Xu, Weijia Fang, Yuping Zhu, Yi Zheng, Xiaofeng Chen, Xiju Xie, Xinhua Hu, Weidong Hu, Jingyu Zheng, Ping Li, Jian Yu, Zhu Mei, Xiaomin Cai, Biao Wang, Zhibin Hu, Yongqian Shu, Hongbing Shen, Yanhong Gu
Format: Article
Language:English
Published: Nature Portfolio 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10987-3

Internet

https://doi.org/10.1038/s41467-019-10987-3

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