P720R USP8 Mutation Is Associated with a Better Responsiveness to Pasireotide in ACTH-Secreting PitNETs

P720R USP8 Mutation Is Associated with a Better Responsiveness to Pasireotide in ACTH-Secreting PitNETs

Somatic mutations in the ubiquitin specific peptidase 8 (USP8) gene have been associated with higher levels of somatostatin (SS) receptor subtype 5 (SSTR5) in adrenocorticotroph hormone (ACTH)-secreting pituitary neuroendocrine tumors (PitNETs). However, a correlation between the USP8 mutational sta...

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Bibliographic Details
Main Authors: Donatella Treppiedi, Giusy Marra, Genesio Di Muro, Emanuela Esposito, Anna Maria Barbieri, Rosa Catalano, Federica Mangili, Francesca Bravi, Marco Locatelli, Andrea Gerardo Lania, Emanuele Ferrante, Rita Indirli, Emma Nozza, Federico Arlati, Anna Spada, Maura Arosio, Giovanna Mantovani, Erika Peverelli
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
ACTH-secreting PitNETs
USP8
pasireotide
molecular marker
Online Access:https://www.mdpi.com/2072-6694/14/10/2455

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