Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure.
Although Plasmodium vivax contributes to almost half of all malaria cases outside Africa, it has been relatively neglected compared to the more deadly P. falciparum. It is known that P. vivax populations possess high genetic diversity, differing geographically potentially due to different vector spe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5426636?pdf=render |
| _version_ | 1811231873559429120 |
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| author | Ernest Diez Benavente Zoe Ward Wilson Chan Fady R Mohareb Colin J Sutherland Cally Roper Susana Campino Taane G Clark |
| author_facet | Ernest Diez Benavente Zoe Ward Wilson Chan Fady R Mohareb Colin J Sutherland Cally Roper Susana Campino Taane G Clark |
| author_sort | Ernest Diez Benavente |
| collection | DOAJ |
| description | Although Plasmodium vivax contributes to almost half of all malaria cases outside Africa, it has been relatively neglected compared to the more deadly P. falciparum. It is known that P. vivax populations possess high genetic diversity, differing geographically potentially due to different vector species, host genetics and environmental factors.We analysed the high-quality genomic data for 46 P. vivax isolates spanning 10 countries across 4 continents. Using population genetic methods we identified hotspots of selection pressure, including the previously reported MRP1 and DHPS genes, both putative drug resistance loci. Extra copies and deletions in the promoter region of another drug resistance candidate, MDR1 gene, and duplications in the Duffy binding protein gene (PvDBP) potentially involved in erythrocyte invasion, were also identified. For surveillance applications, continental-informative markers were found in putative drug resistance loci, and we show that organellar polymorphisms could classify P. vivax populations across continents and differentiate between Plasmodia spp.This study has shown that genomic diversity that lies within and between P. vivax populations can be used to elucidate potential drug resistance and invasion mechanisms, as well as facilitate the molecular barcoding of the parasite for surveillance applications. |
| first_indexed | 2024-04-12T10:53:38Z |
| format | Article |
| id | doaj.art-972203418f0a4565ab26ea7723cd795c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T10:53:38Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-972203418f0a4565ab26ea7723cd795c2022-12-22T03:36:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017713410.1371/journal.pone.0177134Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure.Ernest Diez BenaventeZoe WardWilson ChanFady R MoharebColin J SutherlandCally RoperSusana CampinoTaane G ClarkAlthough Plasmodium vivax contributes to almost half of all malaria cases outside Africa, it has been relatively neglected compared to the more deadly P. falciparum. It is known that P. vivax populations possess high genetic diversity, differing geographically potentially due to different vector species, host genetics and environmental factors.We analysed the high-quality genomic data for 46 P. vivax isolates spanning 10 countries across 4 continents. Using population genetic methods we identified hotspots of selection pressure, including the previously reported MRP1 and DHPS genes, both putative drug resistance loci. Extra copies and deletions in the promoter region of another drug resistance candidate, MDR1 gene, and duplications in the Duffy binding protein gene (PvDBP) potentially involved in erythrocyte invasion, were also identified. For surveillance applications, continental-informative markers were found in putative drug resistance loci, and we show that organellar polymorphisms could classify P. vivax populations across continents and differentiate between Plasmodia spp.This study has shown that genomic diversity that lies within and between P. vivax populations can be used to elucidate potential drug resistance and invasion mechanisms, as well as facilitate the molecular barcoding of the parasite for surveillance applications.http://europepmc.org/articles/PMC5426636?pdf=render |
| spellingShingle | Ernest Diez Benavente Zoe Ward Wilson Chan Fady R Mohareb Colin J Sutherland Cally Roper Susana Campino Taane G Clark Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. PLoS ONE |
| title | Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. |
| title_full | Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. |
| title_fullStr | Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. |
| title_full_unstemmed | Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. |
| title_short | Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. |
| title_sort | genomic variation in plasmodium vivax malaria reveals regions under selective pressure |
| url | http://europepmc.org/articles/PMC5426636?pdf=render |
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