Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future
Acephalic spermatozoa syndrome (ASS) is one of the most severe spermatogenic failures of all infertility in men. The cognition of ASS has experienced a tortuous process. Over the past years, with the in-depth understanding of spermatogenesis and the emergence of new genetic research technologies, th...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=3;spage=231;epage=237;aulast=Wang |
| _version_ | 1818234735945580544 |
|---|---|
| author | Yu Wang Ming-Fei Xiang Na Zheng Yun-Xia Cao Fu-Xi Zhu |
| author_facet | Yu Wang Ming-Fei Xiang Na Zheng Yun-Xia Cao Fu-Xi Zhu |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Acephalic spermatozoa syndrome (ASS) is one of the most severe spermatogenic failures of all infertility in men. The cognition of ASS has experienced a tortuous process. Over the past years, with the in-depth understanding of spermatogenesis and the emergence of new genetic research technologies, the unraveling of the genetic causes of spermatogenic failure has become highly active. From these advances, we established a genetic background and made significant progress in the discovery of the genetic causes of ASS. It is important to identify pathogenic genes and mutations in ASS to determine the biological reasons for the occurrence of the disease as well as provide genetic diagnosis and treatment strategies for patients with this syndrome. In this review, we enumerate various technological developments, which have made a positive contribution to the discovery of candidate genes for ASS from the past to the present. Simultaneously, we summarize the known genetic etiology of this phenotype and the clinical outcomes of treatments in the present. Furthermore, we propose perspectives for further study and application of genetic diagnosis and assisted reproductive treatment in the future. |
| first_indexed | 2024-12-12T11:42:48Z |
| format | Article |
| id | doaj.art-97269beade7e4eadb8202d6d37b7506d |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-12T11:42:48Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-97269beade7e4eadb8202d6d37b7506d2022-12-22T00:25:30ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622022-01-0124323123710.4103/aja202198Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and futureYu WangMing-Fei XiangNa ZhengYun-Xia CaoFu-Xi ZhuAcephalic spermatozoa syndrome (ASS) is one of the most severe spermatogenic failures of all infertility in men. The cognition of ASS has experienced a tortuous process. Over the past years, with the in-depth understanding of spermatogenesis and the emergence of new genetic research technologies, the unraveling of the genetic causes of spermatogenic failure has become highly active. From these advances, we established a genetic background and made significant progress in the discovery of the genetic causes of ASS. It is important to identify pathogenic genes and mutations in ASS to determine the biological reasons for the occurrence of the disease as well as provide genetic diagnosis and treatment strategies for patients with this syndrome. In this review, we enumerate various technological developments, which have made a positive contribution to the discovery of candidate genes for ASS from the past to the present. Simultaneously, we summarize the known genetic etiology of this phenotype and the clinical outcomes of treatments in the present. Furthermore, we propose perspectives for further study and application of genetic diagnosis and assisted reproductive treatment in the future.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=3;spage=231;epage=237;aulast=Wangacephalic spermatozoa syndrome; genetic pathogenesis; male infertility |
| spellingShingle | Yu Wang Ming-Fei Xiang Na Zheng Yun-Xia Cao Fu-Xi Zhu Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future Asian Journal of Andrology acephalic spermatozoa syndrome; genetic pathogenesis; male infertility |
| title | Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future |
| title_full | Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future |
| title_fullStr | Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future |
| title_full_unstemmed | Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future |
| title_short | Genetic pathogenesis of acephalic spermatozoa syndrome: past, present, and future |
| title_sort | genetic pathogenesis of acephalic spermatozoa syndrome past present and future |
| topic | acephalic spermatozoa syndrome; genetic pathogenesis; male infertility |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=3;spage=231;epage=237;aulast=Wang |
| work_keys_str_mv | AT yuwang geneticpathogenesisofacephalicspermatozoasyndromepastpresentandfuture AT mingfeixiang geneticpathogenesisofacephalicspermatozoasyndromepastpresentandfuture AT nazheng geneticpathogenesisofacephalicspermatozoasyndromepastpresentandfuture AT yunxiacao geneticpathogenesisofacephalicspermatozoasyndromepastpresentandfuture AT fuxizhu geneticpathogenesisofacephalicspermatozoasyndromepastpresentandfuture |