SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

The on-going global pandemic of COVID-19 is caused by SARS-CoV-2, which features a proofreading mechanism to facilitate the replication of its large RNA genome. The 3′-to-5′ exoribonuclease (ExoN) activity of SARS-CoV-2 non-structural protein 14 (nsp14) removes nucleotides misincorporated during RNA...

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Bibliographic Details
Main Authors: Nicholas H. Moeller, Kellan T. Passow, Daniel A. Harki, Hideki Aihara
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Viruses
Subjects:
SARS-CoV-2
nsp14
proofreading
chain terminator
ddhCTP
RNA-dependent RNA polymerase
Online Access:https://www.mdpi.com/1999-4915/14/8/1790

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