MicroRNA-21: An Emerging Player in Bone Diseases
MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an importa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.722804/full |
| _version_ | 1818589876935720960 |
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| author | Chen Chen Chen Chen Ya-Mei Liu Bin-Lan Fu Liang-Liang Xu Liang-Liang Xu Bin Wang |
| author_facet | Chen Chen Chen Chen Ya-Mei Liu Bin-Lan Fu Liang-Liang Xu Liang-Liang Xu Bin Wang |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an important role in a variety of physiological and pathological processes. MiRNA-21 (miR-21) is one of them. In recent years, miR-21 has received a lot of attention from researchers as an emerging player in orthopedic diseases. MiR-21 is closely associated with the occurrence, development, treatment, and prevention of orthopedic diseases through a variety of mechanisms. This review summarizes its effects on osteoblasts, osteoclasts and their relationship with osteoporosis, fracture, osteoarthritis (OA), osteonecrosis, providing a new way of thinking for the diagnosis, treatment and prevention of these bone diseases. |
| first_indexed | 2024-12-16T09:47:37Z |
| format | Article |
| id | doaj.art-97278c81981942e6b5cc966e6738ca71 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-16T09:47:37Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-97278c81981942e6b5cc966e6738ca712022-12-21T22:36:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-09-011210.3389/fphar.2021.722804722804MicroRNA-21: An Emerging Player in Bone DiseasesChen Chen0Chen Chen1Ya-Mei Liu2Bin-Lan Fu3Liang-Liang Xu4Liang-Liang Xu5Bin Wang6School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, ChinaLaboratory of Orthopaedics and Traumatology, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, ChinaLaboratory of Orthopaedics and Traumatology, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaKey Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Traumatology, the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaMicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an important role in a variety of physiological and pathological processes. MiRNA-21 (miR-21) is one of them. In recent years, miR-21 has received a lot of attention from researchers as an emerging player in orthopedic diseases. MiR-21 is closely associated with the occurrence, development, treatment, and prevention of orthopedic diseases through a variety of mechanisms. This review summarizes its effects on osteoblasts, osteoclasts and their relationship with osteoporosis, fracture, osteoarthritis (OA), osteonecrosis, providing a new way of thinking for the diagnosis, treatment and prevention of these bone diseases.https://www.frontiersin.org/articles/10.3389/fphar.2021.722804/fullmiRNAsmiR-21osteoblastsosteoclastsbone diseases |
| spellingShingle | Chen Chen Chen Chen Ya-Mei Liu Bin-Lan Fu Liang-Liang Xu Liang-Liang Xu Bin Wang MicroRNA-21: An Emerging Player in Bone Diseases Frontiers in Pharmacology miRNAs miR-21 osteoblasts osteoclasts bone diseases |
| title | MicroRNA-21: An Emerging Player in Bone Diseases |
| title_full | MicroRNA-21: An Emerging Player in Bone Diseases |
| title_fullStr | MicroRNA-21: An Emerging Player in Bone Diseases |
| title_full_unstemmed | MicroRNA-21: An Emerging Player in Bone Diseases |
| title_short | MicroRNA-21: An Emerging Player in Bone Diseases |
| title_sort | microrna 21 an emerging player in bone diseases |
| topic | miRNAs miR-21 osteoblasts osteoclasts bone diseases |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.722804/full |
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