The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy
The efficiency of pregabalin in 49 patients, aged from 18 to 69 years of old, after surgical treatment on account of gliomas of the cerebral hemispheres (I-IV WHO) during radiotherapy in 2006-2010 has been studied. The first group consisted of 24 (48.9%) patients. They had their epileptic seizures b...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-08-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/206 |
| _version_ | 1797879459490037760 |
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| author | A. S. Shershever D. L. Bencion S. A. Lavrova A. J. Lazarev M. A. Zhuravleva V. V. Mahnev J. A. Mironova E. V. Sorokova |
| author_facet | A. S. Shershever D. L. Bencion S. A. Lavrova A. J. Lazarev M. A. Zhuravleva V. V. Mahnev J. A. Mironova E. V. Sorokova |
| author_sort | A. S. Shershever |
| collection | DOAJ |
| description | The efficiency of pregabalin in 49 patients, aged from 18 to 69 years of old, after surgical treatment on account of gliomas of the cerebral hemispheres (I-IV WHO) during radiotherapy in 2006-2010 has been studied. The first group consisted of 24 (48.9%) patients. They had their epileptic seizures before surgery. The second group - 17 (34,7%) - the first attacks occurred against the background of the radiotherapy. The third group - 8 (16,3%) - they have noted the reinforcement or the appearance of epileptiform against the background of the radiotherapy. Taking into account that conducted previously antiepileptic therapy by anticonvulsant was inefficient, pregabalin was used in the mode of polytherapy. Pregabalin doses ranged from 150 to 450 mg / cut. The clinical effect in the form of deceleration of seizures in groups I and II is marked by 3-5 day, p = 0.043. The positive dynamics in the form of reduction or regression of epileptiform activity on EEG was recorded in the period of 7-10 days after the starting the therapy by pregabalin. All patients assessed the level of pain using a ten-point visual analog scale. In this case, a statistically significant difference in the scoring level of pain on the background radiation therapy and receiving pregabalin (p = 0.007) was recognized. All patients completed a course of radiotherapy. «Retention rates» in treatment of pregabalin on the background of the radiotherapy and the next 30 days after discharge from the hospital was 87%. |
| first_indexed | 2024-04-10T02:48:00Z |
| format | Article |
| id | doaj.art-972a1b83a014410bbea4c9cc8837e965 |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:48:00Z |
| publishDate | 2016-08-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-972a1b83a014410bbea4c9cc8837e9652023-03-13T07:44:15ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882016-08-01311016205The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapyA. S. Shershever0D. L. Bencion1S. A. Lavrova2A. J. Lazarev3M. A. Zhuravleva4V. V. Mahnev5J. A. Mironova6E. V. Sorokova7State budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterState budget institution of health of the Sverdlovsk region. Sverdlovsk Regional Oncology CenterThe efficiency of pregabalin in 49 patients, aged from 18 to 69 years of old, after surgical treatment on account of gliomas of the cerebral hemispheres (I-IV WHO) during radiotherapy in 2006-2010 has been studied. The first group consisted of 24 (48.9%) patients. They had their epileptic seizures before surgery. The second group - 17 (34,7%) - the first attacks occurred against the background of the radiotherapy. The third group - 8 (16,3%) - they have noted the reinforcement or the appearance of epileptiform against the background of the radiotherapy. Taking into account that conducted previously antiepileptic therapy by anticonvulsant was inefficient, pregabalin was used in the mode of polytherapy. Pregabalin doses ranged from 150 to 450 mg / cut. The clinical effect in the form of deceleration of seizures in groups I and II is marked by 3-5 day, p = 0.043. The positive dynamics in the form of reduction or regression of epileptiform activity on EEG was recorded in the period of 7-10 days after the starting the therapy by pregabalin. All patients assessed the level of pain using a ten-point visual analog scale. In this case, a statistically significant difference in the scoring level of pain on the background radiation therapy and receiving pregabalin (p = 0.007) was recognized. All patients completed a course of radiotherapy. «Retention rates» in treatment of pregabalin on the background of the radiotherapy and the next 30 days after discharge from the hospital was 87%.https://www.epilepsia.su/jour/article/view/206pregabalincerebral gliomaspartial seizuresradiation therapypainsurgery |
| spellingShingle | A. S. Shershever D. L. Bencion S. A. Lavrova A. J. Lazarev M. A. Zhuravleva V. V. Mahnev J. A. Mironova E. V. Sorokova The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy Эпилепсия и пароксизмальные состояния pregabalin cerebral gliomas partial seizures radiation therapy pain surgery |
| title | The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy |
| title_full | The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy |
| title_fullStr | The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy |
| title_full_unstemmed | The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy |
| title_short | The experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy |
| title_sort | experience of using anticonvulsant pregabalin in patients with cerebral gliomas and partial epileptic seizures after surgical treatment during the radiotherapy |
| topic | pregabalin cerebral gliomas partial seizures radiation therapy pain surgery |
| url | https://www.epilepsia.su/jour/article/view/206 |
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