The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review
Although the use of allogeneic hematopoietic cell transplantation (HCT) for chronic lymphocytic leukemia (CLL) has declined with the development of novel targeted agents, it continues to play an important role for eligible patients with high-risk or heavily pretreated CLL who lack other treatment op...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1105779/full |
| _version_ | 1829455290029834240 |
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| author | Robert Puckrin Mona Shafey Jan Storek |
| author_facet | Robert Puckrin Mona Shafey Jan Storek |
| author_sort | Robert Puckrin |
| collection | DOAJ |
| description | Although the use of allogeneic hematopoietic cell transplantation (HCT) for chronic lymphocytic leukemia (CLL) has declined with the development of novel targeted agents, it continues to play an important role for eligible patients with high-risk or heavily pretreated CLL who lack other treatment options. CLL is susceptible to a potent graft-versus-leukemia (GVL) effect which produces long-lasting remissions in 30-50% of transplanted patients. While allogeneic HCT is associated with significant risks of graft-versus-host disease (GVHD), infection, and non-relapse mortality (NRM), improvements in patient and donor selection, reduced intensity conditioning (RIC), GVHD prophylaxis, and supportive care have rendered this an increasingly safe and effective procedure in the current era. In this review, we discuss recent advances in allogeneic HCT for CLL, with a focus on the optimal evidence-based strategies to maximize benefit and minimize toxicity of this potentially curative cellular therapy. |
| first_indexed | 2024-04-10T22:18:50Z |
| format | Article |
| id | doaj.art-972c7751bfc94e989b3109e147d6553a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T22:18:50Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-972c7751bfc94e989b3109e147d6553a2023-01-18T05:23:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.11057791105779The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A reviewRobert PuckrinMona ShafeyJan StorekAlthough the use of allogeneic hematopoietic cell transplantation (HCT) for chronic lymphocytic leukemia (CLL) has declined with the development of novel targeted agents, it continues to play an important role for eligible patients with high-risk or heavily pretreated CLL who lack other treatment options. CLL is susceptible to a potent graft-versus-leukemia (GVL) effect which produces long-lasting remissions in 30-50% of transplanted patients. While allogeneic HCT is associated with significant risks of graft-versus-host disease (GVHD), infection, and non-relapse mortality (NRM), improvements in patient and donor selection, reduced intensity conditioning (RIC), GVHD prophylaxis, and supportive care have rendered this an increasingly safe and effective procedure in the current era. In this review, we discuss recent advances in allogeneic HCT for CLL, with a focus on the optimal evidence-based strategies to maximize benefit and minimize toxicity of this potentially curative cellular therapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.1105779/fullchronic lymphocytic leukemia (CLL)allogeneic hematopoietic cell transplantgraft-versus-hose disease (GvHD)Conditioninggraft-versus-leukemia (GvL) |
| spellingShingle | Robert Puckrin Mona Shafey Jan Storek The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review Frontiers in Oncology chronic lymphocytic leukemia (CLL) allogeneic hematopoietic cell transplant graft-versus-hose disease (GvHD) Conditioning graft-versus-leukemia (GvL) |
| title | The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review |
| title_full | The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review |
| title_fullStr | The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review |
| title_full_unstemmed | The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review |
| title_short | The role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: A review |
| title_sort | role of allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia a review |
| topic | chronic lymphocytic leukemia (CLL) allogeneic hematopoietic cell transplant graft-versus-hose disease (GvHD) Conditioning graft-versus-leukemia (GvL) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1105779/full |
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