The LRRC8A Mediated “Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

The LRRC8A Mediated “Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and...

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Bibliographic Details
Main Authors: Philippe Behe, Juliet R. Foote, Adam P. Levine, Craig D. Platt, Janet Chou, Fernando Benavides, Raif S. Geha, Anthony W. Segal
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
neutrophil
vacuolar homeostasis
NADPH oxidase
ion channel
chloride
VSOR Cl- current
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00262/full

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