Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90
In radiobiology circulating T-lymphocytes are used as “natural biodosimeters” since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to the accumulated dose. In addition, stable chromosomal aberrations (translocations) are detected in them years an...
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| Format: | Article |
| Language: | English |
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Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev
2022-10-01
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| Series: | Радиационная гигиена |
| Subjects: | |
| Online Access: | https://www.radhyg.ru/jour/article/view/893 |
| _version_ | 1797873804852068352 |
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| author | E. I. Tolstykh M. O. Degteva |
| author_facet | E. I. Tolstykh M. O. Degteva |
| author_sort | E. I. Tolstykh |
| collection | DOAJ |
| description | In radiobiology circulating T-lymphocytes are used as “natural biodosimeters” since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to the accumulated dose. In addition, stable chromosomal aberrations (translocations) are detected in them years and decades after radiation exposure. Estimation of doses to circulating lymphocytes requires consideration of two dose components: the dose accumulated by the lymphocyte precursors (progenitors) in the red bone marrow; and dose accumulated by the lymphocytes in the lymphoid organs/tissues during circulation. A recently created model of T-lymphocyte exposure takes into account all these dose components, as well as the age-dependent dynamics of T-lymphocytes. The use of a model approach is especially important in assessing doses from osteotropic beta emitters (89,90Sr). They accumulate in the bone and locally expose predominately bone marrow. The dose to other lymphoid organs and tissues is much lower. The objective of this study is to evaluate the conversion factors from ingested 89,90Sr to the cumulative dose to circulating T-lymphocytes and their progenitors (DCL). For calculations, the previously developed model of T-lymphocyte exposure and new dose coefficients for the red bone marrow, estimated on the basis of a sex-and-age-dependent biokinetic model and a new dosimetric model of the human skeleton were used. As a result, the DCL values were evaluated for the first time. The age at the time of 89,90Sr intake varied from a newborn to 35 years, the age of T-lymphocyte examination (blood sampling age) was up to 75 years. The maximum values of DCL for both 90Sr and 89Sr were typical of children in the first years of life. It has been shown that doses to circulating T-lymphocytes from these radionuclides are lower than those to bone marrow, but are significantly higher than doses to other lymphoid tissues. The effect of sex on DCL is manifested for children 10 years of age and older. The area of DCL application covers the population of radioactively contaminated territories (the Urals region, the zone of the Chernobyl accident), as well as personnel of the nuclear industry enterprises. |
| first_indexed | 2024-04-10T01:20:48Z |
| format | Article |
| id | doaj.art-972d19ae1da14b6aa88648e2a7cb3e1c |
| institution | Directory Open Access Journal |
| issn | 1998-426X |
| language | English |
| last_indexed | 2024-04-10T01:20:48Z |
| publishDate | 2022-10-01 |
| publisher | Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev |
| record_format | Article |
| series | Радиационная гигиена |
| spelling | doaj.art-972d19ae1da14b6aa88648e2a7cb3e1c2023-03-13T09:47:12ZengSaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. RamzaevРадиационная гигиена1998-426X2022-10-01153829110.21514/1998-426X-2022-15-3-82-91761Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90E. I. Tolstykh0M. O. Degteva1Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства РоссииУральский научно-практический центр радиационной медицины Федерального медико-биологического агентства РоссииIn radiobiology circulating T-lymphocytes are used as “natural biodosimeters” since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to the accumulated dose. In addition, stable chromosomal aberrations (translocations) are detected in them years and decades after radiation exposure. Estimation of doses to circulating lymphocytes requires consideration of two dose components: the dose accumulated by the lymphocyte precursors (progenitors) in the red bone marrow; and dose accumulated by the lymphocytes in the lymphoid organs/tissues during circulation. A recently created model of T-lymphocyte exposure takes into account all these dose components, as well as the age-dependent dynamics of T-lymphocytes. The use of a model approach is especially important in assessing doses from osteotropic beta emitters (89,90Sr). They accumulate in the bone and locally expose predominately bone marrow. The dose to other lymphoid organs and tissues is much lower. The objective of this study is to evaluate the conversion factors from ingested 89,90Sr to the cumulative dose to circulating T-lymphocytes and their progenitors (DCL). For calculations, the previously developed model of T-lymphocyte exposure and new dose coefficients for the red bone marrow, estimated on the basis of a sex-and-age-dependent biokinetic model and a new dosimetric model of the human skeleton were used. As a result, the DCL values were evaluated for the first time. The age at the time of 89,90Sr intake varied from a newborn to 35 years, the age of T-lymphocyte examination (blood sampling age) was up to 75 years. The maximum values of DCL for both 90Sr and 89Sr were typical of children in the first years of life. It has been shown that doses to circulating T-lymphocytes from these radionuclides are lower than those to bone marrow, but are significantly higher than doses to other lymphoid tissues. The effect of sex on DCL is manifested for children 10 years of age and older. The area of DCL application covers the population of radioactively contaminated territories (the Urals region, the zone of the Chernobyl accident), as well as personnel of the nuclear industry enterprises.https://www.radhyg.ru/jour/article/view/893т-лимфоцитыдозовые коэффициенты8990srвнутреннее облучениебиодозиметрия |
| spellingShingle | E. I. Tolstykh M. O. Degteva Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90 Радиационная гигиена т-лимфоциты дозовые коэффициенты 89 90sr внутреннее облучение биодозиметрия |
| title | Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90 |
| title_full | Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90 |
| title_fullStr | Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90 |
| title_full_unstemmed | Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90 |
| title_short | Estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium-89,90 |
| title_sort | estimation of radiation doses on lymphocytes and their progenitors after ingestion of strontium 89 90 |
| topic | т-лимфоциты дозовые коэффициенты 89 90sr внутреннее облучение биодозиметрия |
| url | https://www.radhyg.ru/jour/article/view/893 |
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