Mitochondrial DNA Mutations in Grade II and III Glioma Cell Lines Are Associated with Significant Mitochondrial Dysfunction and Higher Oxidative Stress

Mitochondrial DNA Mutations in Grade II and III Glioma Cell Lines Are Associated with Significant Mitochondrial Dysfunction and Higher Oxidative Stress

The role of mitochondria in tumorigenesis has regained much attention as it could dysregulate cellular energetics, oxidative stress and apoptosis. However, the role of mitochondria in different grade gliomasis still unknown. This study aimed to identify mitochondrial DNA (mtDNA) sequence variations...

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Bibliographic Details
Main Authors: Nor Azian Abdul Murad, Rahman Jamal, Bee Hong Soon, Sue-Mian Then, Azizi Abu Bakar, Farizal Fadzil, Jegan Thanabalan, Mohd S. Mohd Haspani, Charng Jeng Toh, Azmi Mohd Tamil, Roslan Harun, Wan Z. Wan Ngah
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Physiology
Subjects:
gliomas
mitochondrial DNA mutation
mitochondrial dysfunction
oxidative stress
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00231/full

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