The Roles of microRNA miR-185 in Digestive Tract Cancers
Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node meta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/8/5/67 |
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| author | Esmaeel Babaeenezhad Fakhraddin Naghibalhossaini Masoumeh Rajabibazl Zohreh Jangravi Forouzan Hadipour Moradi Mohammad Davood Fattahi Jörg D. Hoheisel Mostafa Moradi Sarabi Soroosh Shahryarhesami |
| author_facet | Esmaeel Babaeenezhad Fakhraddin Naghibalhossaini Masoumeh Rajabibazl Zohreh Jangravi Forouzan Hadipour Moradi Mohammad Davood Fattahi Jörg D. Hoheisel Mostafa Moradi Sarabi Soroosh Shahryarhesami |
| author_sort | Esmaeel Babaeenezhad |
| collection | DOAJ |
| description | Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches. |
| first_indexed | 2024-03-09T19:39:37Z |
| format | Article |
| id | doaj.art-972dbb55c0004dfbab56d0d6f900fb92 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-09T19:39:37Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-972dbb55c0004dfbab56d0d6f900fb922023-11-24T01:42:28ZengMDPI AGNon-Coding RNA2311-553X2022-10-01856710.3390/ncrna8050067The Roles of microRNA miR-185 in Digestive Tract CancersEsmaeel Babaeenezhad0Fakhraddin Naghibalhossaini1Masoumeh Rajabibazl2Zohreh Jangravi3Forouzan Hadipour Moradi4Mohammad Davood Fattahi5Jörg D. Hoheisel6Mostafa Moradi Sarabi7Soroosh Shahryarhesami8Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran 1435916471, IranDepartment of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134814336, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranDepartment of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran 1435916471, IranRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad 6813816314, IranDepartment of Clinical Biochemistry, School of Medicine, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranFunctional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, GermanyNutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad 6813816314, IranFunctional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, GermanyDigestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches.https://www.mdpi.com/2311-553X/8/5/67miR-185tumor suppressoroncomiRoral cancergastrointestinal cancerepigenetics |
| spellingShingle | Esmaeel Babaeenezhad Fakhraddin Naghibalhossaini Masoumeh Rajabibazl Zohreh Jangravi Forouzan Hadipour Moradi Mohammad Davood Fattahi Jörg D. Hoheisel Mostafa Moradi Sarabi Soroosh Shahryarhesami The Roles of microRNA miR-185 in Digestive Tract Cancers Non-Coding RNA miR-185 tumor suppressor oncomiR oral cancer gastrointestinal cancer epigenetics |
| title | The Roles of microRNA miR-185 in Digestive Tract Cancers |
| title_full | The Roles of microRNA miR-185 in Digestive Tract Cancers |
| title_fullStr | The Roles of microRNA miR-185 in Digestive Tract Cancers |
| title_full_unstemmed | The Roles of microRNA miR-185 in Digestive Tract Cancers |
| title_short | The Roles of microRNA miR-185 in Digestive Tract Cancers |
| title_sort | roles of microrna mir 185 in digestive tract cancers |
| topic | miR-185 tumor suppressor oncomiR oral cancer gastrointestinal cancer epigenetics |
| url | https://www.mdpi.com/2311-553X/8/5/67 |
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