Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines
The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of <i>N</i>-phosphonyl/phosphoryl imines remained less explored as compared to other <i>N</i>-substituted imines. The chiral a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3524 |
| _version_ | 1797604110752546816 |
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| author | Devalina Ray Suman Majee Ram Naresh Yadav Bimal Krishna Banik |
| author_facet | Devalina Ray Suman Majee Ram Naresh Yadav Bimal Krishna Banik |
| author_sort | Devalina Ray |
| collection | DOAJ |
| description | The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of <i>N</i>-phosphonyl/phosphoryl imines remained less explored as compared to other <i>N</i>-substituted imines. The chiral auxiliary-based asymmetric-induction strategy with <i>N</i>-phosphonyl imines could effectively generate enantio- and diastereomeric amine, <i>α</i>,<i>β</i>-diamine, and other products through various reactions. On the other hand, the asymmetric approach for the generation of chirality through the utilization of optically active ligands, along with metal catalysts, could be successfully implemented on <i>N</i>-phosphonyl/phosphoryl imines to access numerous synthetically challenging chiral amine scaffolds. The current review critically summarizes and reveals the literature precedence of more than a decade to highlight the major achievements existing to date that can display a clear picture of advancement as well drawbacks in this area. |
| first_indexed | 2024-03-11T04:41:41Z |
| format | Article |
| id | doaj.art-972f5869fac04daa8dba552b3c5a4e87 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:41Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-972f5869fac04daa8dba552b3c5a4e872023-11-17T20:40:14ZengMDPI AGMolecules1420-30492023-04-01288352410.3390/molecules28083524Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl IminesDevalina Ray0Suman Majee1Ram Naresh Yadav2Bimal Krishna Banik3Amity Institute of Biotechnology, Amity University, Sector 125, Noida 201313, UP, IndiaAmity Institute of Biotechnology, Amity University, Sector 125, Noida 201313, UP, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Veer Bahadur Singh Purvanchal University, Jaunpur 222003, UP, IndiaDepartment of Mathematics and Natural Sciences, College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar 31952, Saudi ArabiaThe asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of <i>N</i>-phosphonyl/phosphoryl imines remained less explored as compared to other <i>N</i>-substituted imines. The chiral auxiliary-based asymmetric-induction strategy with <i>N</i>-phosphonyl imines could effectively generate enantio- and diastereomeric amine, <i>α</i>,<i>β</i>-diamine, and other products through various reactions. On the other hand, the asymmetric approach for the generation of chirality through the utilization of optically active ligands, along with metal catalysts, could be successfully implemented on <i>N</i>-phosphonyl/phosphoryl imines to access numerous synthetically challenging chiral amine scaffolds. The current review critically summarizes and reveals the literature precedence of more than a decade to highlight the major achievements existing to date that can display a clear picture of advancement as well drawbacks in this area.https://www.mdpi.com/1420-3049/28/8/3524asymmetric synthesis<i>N</i>-phosphoryl/phosphonyl iminesstereoselectivechiral catalysisligands |
| spellingShingle | Devalina Ray Suman Majee Ram Naresh Yadav Bimal Krishna Banik Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines Molecules asymmetric synthesis <i>N</i>-phosphoryl/phosphonyl imines stereoselective chiral catalysis ligands |
| title | Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines |
| title_full | Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines |
| title_fullStr | Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines |
| title_full_unstemmed | Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines |
| title_short | Asymmetric Reactions of <i>N</i>-Phosphonyl/Phosphoryl Imines |
| title_sort | asymmetric reactions of i n i phosphonyl phosphoryl imines |
| topic | asymmetric synthesis <i>N</i>-phosphoryl/phosphonyl imines stereoselective chiral catalysis ligands |
| url | https://www.mdpi.com/1420-3049/28/8/3524 |
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