Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report
Abstract Rapid and reliable identification of targetable driver mutations in patients with advanced stage lung cancer is essential. Adequate amount of tumor tissue biopsies (i.e., genomic biopsies) are required to successfully analyze the gene panel. In the present case, we performed three pleural f...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14738 |
| _version_ | 1828076104003354624 |
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| author | Kei Kunimasa Takako Inoue Yugo Kai Ryu Kanzaki Sachi Kawagishi Ken‐ichi Yoshida Keiichiro Honma Motohiro Tamiya Takahisa Kawamura Kazumi Nishino |
| author_facet | Kei Kunimasa Takako Inoue Yugo Kai Ryu Kanzaki Sachi Kawagishi Ken‐ichi Yoshida Keiichiro Honma Motohiro Tamiya Takahisa Kawamura Kazumi Nishino |
| author_sort | Kei Kunimasa |
| collection | DOAJ |
| description | Abstract Rapid and reliable identification of targetable driver mutations in patients with advanced stage lung cancer is essential. Adequate amount of tumor tissue biopsies (i.e., genomic biopsies) are required to successfully analyze the gene panel. In the present case, we performed three pleural fluid investigations, including transbronchial biopsy of the primary tumor, transesophageal endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) of lymph node metastasis, and thoracoscopic biopsy of the pleural seeding sites. Among the three investigations, thoracoscopic biopsy alone successfully obtained a sufficient amount of tissue. Thus, it is important to determine the technique and site of biopsy, as multiple biopsies are not only burdensome to the patient, but also lead to significant delays in therapy induction. |
| first_indexed | 2024-04-11T02:09:45Z |
| format | Article |
| id | doaj.art-972f9ed6b072498085c902e50ee20f7c |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T02:09:45Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-972f9ed6b072498085c902e50ee20f7c2023-01-03T02:26:19ZengWileyThoracic Cancer1759-77061759-77142023-01-01141858810.1111/1759-7714.14738Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case reportKei Kunimasa0Takako Inoue1Yugo Kai2Ryu Kanzaki3Sachi Kawagishi4Ken‐ichi Yoshida5Keiichiro Honma6Motohiro Tamiya7Takahisa Kawamura8Kazumi Nishino9Department of Thoracic Oncology Osaka International Cancer Institute Osaka JapanDepartment of Thoracic Oncology Osaka International Cancer Institute Osaka JapanDepartment of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute Osaka JapanDepartment of General Thoracic Surgery Osaka International Cancer Institute Osaka JapanDepartment of General Thoracic Surgery Osaka International Cancer Institute Osaka JapanDepartment of Diagnostic Pathology and Cytology Osaka International Cancer Institute Osaka JapanDepartment of Diagnostic Pathology and Cytology Osaka International Cancer Institute Osaka JapanDepartment of Thoracic Oncology Osaka International Cancer Institute Osaka JapanDepartment of Thoracic Oncology Osaka International Cancer Institute Osaka JapanDepartment of Thoracic Oncology Osaka International Cancer Institute Osaka JapanAbstract Rapid and reliable identification of targetable driver mutations in patients with advanced stage lung cancer is essential. Adequate amount of tumor tissue biopsies (i.e., genomic biopsies) are required to successfully analyze the gene panel. In the present case, we performed three pleural fluid investigations, including transbronchial biopsy of the primary tumor, transesophageal endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) of lymph node metastasis, and thoracoscopic biopsy of the pleural seeding sites. Among the three investigations, thoracoscopic biopsy alone successfully obtained a sufficient amount of tissue. Thus, it is important to determine the technique and site of biopsy, as multiple biopsies are not only burdensome to the patient, but also lead to significant delays in therapy induction.https://doi.org/10.1111/1759-7714.14738gene panelgenomic biopsylung cancerrapid on‐site evaluationthoracoscopy |
| spellingShingle | Kei Kunimasa Takako Inoue Yugo Kai Ryu Kanzaki Sachi Kawagishi Ken‐ichi Yoshida Keiichiro Honma Motohiro Tamiya Takahisa Kawamura Kazumi Nishino Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report Thoracic Cancer gene panel genomic biopsy lung cancer rapid on‐site evaluation thoracoscopy |
| title | Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report |
| title_full | Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report |
| title_fullStr | Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report |
| title_full_unstemmed | Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report |
| title_short | Rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer: A case report |
| title_sort | rapid and reliable collection of tumor tissue for successful gene panel in a patient with advanced stage lung cancer a case report |
| topic | gene panel genomic biopsy lung cancer rapid on‐site evaluation thoracoscopy |
| url | https://doi.org/10.1111/1759-7714.14738 |
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