Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta

Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta

Placental insufficiency is implicated in spontaneous preterm birth (SPTB) associated with intrauterine inflammation. We hypothesized that intrauterine inflammation leads to deficits in the capacity of the placenta to maintain bioenergetic and metabolic stability during pregnancy ultimately resulting...

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Bibliographic Details
Main Authors: Yu-Chin Lien, Zhe Zhang, Guillermo Barila, Amy Green-Brown, Michal A. Elovitz, Rebecca A. Simmons
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
placenta
transcriptome
metabolome
inflammation
spontaneous preterm birth
bioenergetic metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.592689/full

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