Effect of IGF1Rβ Subunit Mutants on Proliferation, Migration and Apoptosis of Human Osteosarcoma Cells

Effect of IGF1Rβ Subunit Mutants on Proliferation, Migration and Apoptosis of Human Osteosarcoma Cells

Objective To investigate the effect of IGF1R β subunit mutants sb-IGF1R and ma-IGF1R on the biological behavior of osteosarcoma 143B cells. Methods We designed and constructed sb-IGF1R and ma-IGF1R fragments. They were cloned into adenovirus AdEasy shuttle plasmid, to obtain Ad-sbIGF1R and Ad-maIGF1...

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Bibliographic Details
Main Authors: WEN Zhongchi1, LIU Tuozhou1, HE Hongbo, ZHANG Can, LIU Yupeng, LIAO Zhan, ZENG Liyi
Format: Article
Language:zho
Published: Magazine House of Cancer Research on Prevention and Treatment 2022-05-01
Series:Zhongliu Fangzhi Yanjiu
Subjects:
insulin-like growth factor 1 receptor
osteosarcoma
mutant
Online Access:http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1104

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