Potential Medication Incompatibilities In Pediatric Oncology Prescriptions
Introduction: Pediatric oncology patients have a limited number of venous access routes and need a large number of drugs during hospitalization. This study evaluates potential MI in pediatric oncology prescriptions and identifies possible factors associated with the risk of their occurrence. Methods...
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| Format: | Article |
| Language: | English |
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Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)
2023-03-01
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| Series: | Clinical and Biomedical Research |
| Subjects: | |
| Online Access: | https://seer.ufrgs.br/index.php/hcpa/article/view/120920 |
| _version_ | 1811160043721064448 |
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| author | Maitê Telles dos Santos Bruno Simas da Rocha Gabriela Wunsch Lopes Débora Kempf da Silva Giovanna Webster Negretto Lauro José Gregianin |
| author_facet | Maitê Telles dos Santos Bruno Simas da Rocha Gabriela Wunsch Lopes Débora Kempf da Silva Giovanna Webster Negretto Lauro José Gregianin |
| author_sort | Maitê Telles dos Santos |
| collection | DOAJ |
| description | Introduction: Pediatric oncology patients have a limited number of venous access routes and need a large number of drugs during hospitalization. This study evaluates potential MI in pediatric oncology prescriptions and identifies possible factors associated with the risk of their occurrence. Methods: Cross-sectional study that evaluated prescriptions from a universitary and tertiary hospital from december 2014 to december 2015. The association between the variables and the risk to potential incompatibilities between drugs was determined by Student’s t test and Pearson’s chi-square, considering p<0.05 significant. Odds Ratio was calculated considering a confidence interval of 95% to each drug. Results: 385 prescriptions were evaluated. The average age from 124 patients was 9.22 years old (SD = ± 5.10), being 50.65% male. The most frequent diagnosis and reason for hospitalization were the leukemias (27.30%) and chemotherapy administration (36.10%). The fully implantable catheter was the most commonly used venous access, in 61.30% of patients. In 87.5% of prescriptions there was the possibility of MI, and a total of 2108 incompatibilities were found, considering 300 different combinations between two drugs. Age, diagnosis, reason for hospitalization and type of venous access were presented as risk factors for potential incompatibilities (p<0.05). Some of the drugs that presented higher risk to potential incompatibilities were: leucovorin, sodium bicarbonate, cefepime, diphenhydramine,dimenhydrinate,hydrocortisone and ondansetron with significant Odds Ratio. Conclusions: the possibility of MI in prescriptions of pediatric oncology patients is frequent. Thus, the identification of risk factors may contribute to patient safety and rational use of drugs.
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| first_indexed | 2024-04-10T05:50:57Z |
| format | Article |
| id | doaj.art-973135a78264484b9cdf2322a28b36da |
| institution | Directory Open Access Journal |
| issn | 2357-9730 |
| language | English |
| last_indexed | 2024-04-10T05:50:57Z |
| publishDate | 2023-03-01 |
| publisher | Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) |
| record_format | Article |
| series | Clinical and Biomedical Research |
| spelling | doaj.art-973135a78264484b9cdf2322a28b36da2023-03-04T18:06:46ZengHospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)Clinical and Biomedical Research2357-97302023-03-01424Potential Medication Incompatibilities In Pediatric Oncology PrescriptionsMaitê Telles dos Santos0Bruno Simas da Rocha1Gabriela Wunsch Lopes2Débora Kempf da Silva3Giovanna Webster Negretto4Lauro José Gregianin5Programa de Pós Graduação em Saúde da Criança e do Adolescente - Universidade Federal do Rio Grande do SulSeção de Farmácia Clínica - Hospital de Clínicas de Porto AlegreFaculdade de Medicina - Universidade Federal do Rio Grande do SulFaculdade de Medicina - Universidade Federal do Rio Grande do SulSeção de Farmácia Clínica - Hospital de Clínicas de Porto AlegrePrograma de Pós Graduação em Saúde da Criança e do Adolescente - Universidade Federal do Rio Grande do SulIntroduction: Pediatric oncology patients have a limited number of venous access routes and need a large number of drugs during hospitalization. This study evaluates potential MI in pediatric oncology prescriptions and identifies possible factors associated with the risk of their occurrence. Methods: Cross-sectional study that evaluated prescriptions from a universitary and tertiary hospital from december 2014 to december 2015. The association between the variables and the risk to potential incompatibilities between drugs was determined by Student’s t test and Pearson’s chi-square, considering p<0.05 significant. Odds Ratio was calculated considering a confidence interval of 95% to each drug. Results: 385 prescriptions were evaluated. The average age from 124 patients was 9.22 years old (SD = ± 5.10), being 50.65% male. The most frequent diagnosis and reason for hospitalization were the leukemias (27.30%) and chemotherapy administration (36.10%). The fully implantable catheter was the most commonly used venous access, in 61.30% of patients. In 87.5% of prescriptions there was the possibility of MI, and a total of 2108 incompatibilities were found, considering 300 different combinations between two drugs. Age, diagnosis, reason for hospitalization and type of venous access were presented as risk factors for potential incompatibilities (p<0.05). Some of the drugs that presented higher risk to potential incompatibilities were: leucovorin, sodium bicarbonate, cefepime, diphenhydramine,dimenhydrinate,hydrocortisone and ondansetron with significant Odds Ratio. Conclusions: the possibility of MI in prescriptions of pediatric oncology patients is frequent. Thus, the identification of risk factors may contribute to patient safety and rational use of drugs. https://seer.ufrgs.br/index.php/hcpa/article/view/120920Drug IncompatibilityOncology ServiceIntravenous infusionsPediatricPatient Safety. |
| spellingShingle | Maitê Telles dos Santos Bruno Simas da Rocha Gabriela Wunsch Lopes Débora Kempf da Silva Giovanna Webster Negretto Lauro José Gregianin Potential Medication Incompatibilities In Pediatric Oncology Prescriptions Clinical and Biomedical Research Drug Incompatibility Oncology Service Intravenous infusions Pediatric Patient Safety. |
| title | Potential Medication Incompatibilities In Pediatric Oncology Prescriptions |
| title_full | Potential Medication Incompatibilities In Pediatric Oncology Prescriptions |
| title_fullStr | Potential Medication Incompatibilities In Pediatric Oncology Prescriptions |
| title_full_unstemmed | Potential Medication Incompatibilities In Pediatric Oncology Prescriptions |
| title_short | Potential Medication Incompatibilities In Pediatric Oncology Prescriptions |
| title_sort | potential medication incompatibilities in pediatric oncology prescriptions |
| topic | Drug Incompatibility Oncology Service Intravenous infusions Pediatric Patient Safety. |
| url | https://seer.ufrgs.br/index.php/hcpa/article/view/120920 |
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