Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice
BackgroundEarlier studies have reported conflicting results regarding long-term behavioral consequences after anesthesia during the fetal period. Previous studies also suggest several factors that may explain such conflicting data. Thus, we examined the influence of age and sex on long-term behavior...
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2017-12-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-70-642.pdf |
| _version_ | 1818255000061607936 |
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| author | Woosuk Chung Seunghwan Yoon Yong Sup Shin |
| author_facet | Woosuk Chung Seunghwan Yoon Yong Sup Shin |
| author_sort | Woosuk Chung |
| collection | DOAJ |
| description | BackgroundEarlier studies have reported conflicting results regarding long-term behavioral consequences after anesthesia during the fetal period. Previous studies also suggest several factors that may explain such conflicting data. Thus, we examined the influence of age and sex on long-term behavioral consequences after multiple sevoflurane exposures during the fetal period.MethodsC57BL/6J pregnant mice received oxygen with or without sevoflurane for 2 hours at gestational day (GD) 14-16. Offspring mice were subjected to behavioral assays for general activity (open field test), learning, and memory (fear chamber test) at postnatal day 30–35.ResultsMultiple sevoflurane exposures at GD 14–16 caused significant changes during the fear chamber test in young female offspring mice. Such changes did not occur in young male offspring mice. However, general activity was not affected in both male and female mice.ConclusionsMultiple sevoflurane exposures in the second trimester of pregnancy affects learning and memory only in young female mice. Further studies focusing on diverse cognitive functions in an age-, sex-dependent manner may provide valuable insights regarding anesthesia-induced neurotoxicity. |
| first_indexed | 2024-12-12T17:04:54Z |
| format | Article |
| id | doaj.art-973141d9ce324401b9898d9fbf792f6c |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-12T17:04:54Z |
| publishDate | 2017-12-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-973141d9ce324401b9898d9fbf792f6c2022-12-22T00:18:01ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632017-12-0170664264710.4097/kjae.2017.70.6.6428363Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring miceWoosuk Chung0Seunghwan Yoon1Yong Sup Shin2Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, Korea.Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, Korea.BackgroundEarlier studies have reported conflicting results regarding long-term behavioral consequences after anesthesia during the fetal period. Previous studies also suggest several factors that may explain such conflicting data. Thus, we examined the influence of age and sex on long-term behavioral consequences after multiple sevoflurane exposures during the fetal period.MethodsC57BL/6J pregnant mice received oxygen with or without sevoflurane for 2 hours at gestational day (GD) 14-16. Offspring mice were subjected to behavioral assays for general activity (open field test), learning, and memory (fear chamber test) at postnatal day 30–35.ResultsMultiple sevoflurane exposures at GD 14–16 caused significant changes during the fear chamber test in young female offspring mice. Such changes did not occur in young male offspring mice. However, general activity was not affected in both male and female mice.ConclusionsMultiple sevoflurane exposures in the second trimester of pregnancy affects learning and memory only in young female mice. Further studies focusing on diverse cognitive functions in an age-, sex-dependent manner may provide valuable insights regarding anesthesia-induced neurotoxicity.http://ekja.org/upload/pdf/kjae-70-642.pdffetuslearningmemorypregnancysevofluranetoxicity |
| spellingShingle | Woosuk Chung Seunghwan Yoon Yong Sup Shin Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice Korean Journal of Anesthesiology fetus learning memory pregnancy sevoflurane toxicity |
| title | Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice |
| title_full | Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice |
| title_fullStr | Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice |
| title_full_unstemmed | Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice |
| title_short | Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice |
| title_sort | multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice |
| topic | fetus learning memory pregnancy sevoflurane toxicity |
| url | http://ekja.org/upload/pdf/kjae-70-642.pdf |
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